关键词: 慢性乙型肝炎, 肝纤维化, 肝脏瞬时弹性检测仪, 肝脏硬度检测, Ishak评分, 诊断

Abstract: Objective To analyze the diagnostic efficacy of hepatic fibrosis by liver stiffness measurement （LSM） in patients with chronic hepatitis B（CHB）. Methods 112 patients with CHB and 30 healthy volunteers were recruited between January 2016 and July 2018,and LSM was detected by FibroTouch. The liver biopsies were conducted in all patients with CHB and the hepatic fibrosis staging were performed by Ishak scoring system. The diagnostic efficacy of hepatic fibrosis by LSM was analyzed by area under the receiver operating characteristic （AUC）. Results Out of the 112 patients with CHB,the hepatic fibrosis stage S0 was found in 16（14.3%）,mild hepatic fibrosis stage S1 was found in 40（35.7%）,moderate hepatic fibrosis S2 to S3 was found in 40（35.7%）, and significant hepatic fibrosis stage S4,e.g. liver cirrhosis,was found in 16（14.3%） by Ishak scoring system; the LSM were （5.4±0.8） kPa,（7.1±2.1） kPa,（9.9±2.5） kPa and （15.8±3.4） kPa,respectively,in patients with hepatic fibrosis S0,S1,S2 to S3 and S4,while it was （5.3±0.9） kPa in healthy volunteers;by setting the LSM=5.90,LSM=7.61,LSM=9.25 and LSM=14.84,respectively,as the cut-off-value for diagnosing hepatic fibrosis S0,S1,S2 to S3 and S4,the AUC were 0.943,0.800,0.568 and 1.000,respectively,and their sensitivities and specificities were 100.0% and 89.6%,100.0% and 69.4%,100.0% and 52.1%,and 100.0% and 100.0%,respectively. Conclusion The application of LSM by FibroTouch examination in diagnosing hepatic fibrosis in patients with CHB is efficacious, which should be further validated in clinical practice.

Key words: Chronic hepatitis B, Liver fibrosis, FibroTouch, Liver stiffness measurement, Ishak scoring system, Diagnosis