实用肝脏病杂志 ›› 2016, Vol. 19 ›› Issue (1): 109-112.doi: 10.3969/j.issn.1672-5069.2016.01.032

• 综述 • 上一篇    下一篇

内生性乙醇与非酒精性脂肪性肝病研究进展*

何崇信, 徐正婕综述, 范建高审校   

  1. 200092 上海市上海交通大学医学院附属新华医院消化科
  • 收稿日期:2015-06-17 出版日期:2016-01-10 发布日期:2016-02-04
  • 通讯作者: 徐正婕,E–mail:ajanexu@163.com
  • 作者简介:何崇信,男,25岁,硕士研究生。主要研究方向为脂肪肝的基础与临床。E–mail:ashinalive@hotmail.com
  • 基金资助:
    *基金项目:国家重点研究发展计划973项目(2012CB517501); 王宝恩抗肝纤维化基金项目(20110006)

Endogenous alcohol in non–alcoholic fatty liver disease

He Chongxin, Xu Zhengjie, Fan Jiangao   

  1. Department of Gastroenterology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092
  • Received:2015-06-17 Online:2016-01-10 Published:2016-02-04

摘要: 非酒精性脂肪性肝病和酒精性肝病具有相似的病理学特征,使得内生性乙醇在非酒精性脂肪性肝病的进展中可能扮演的重要角色成为肝病学家们关注的新方向。内生性乙醇与肝脏、肠道和肠道细菌以及非酒精性脂肪性肝病的关系密切,给我们提供了解释非酒精性脂肪性肝病病因的新视角。

关键词: 非酒精性脂肪性肝病, 内生性乙醇, 肠道细菌

Abstract: Similar pathologic characteristics between non–alcoholic fatty liver disease and alcoholic liver disease presents a new direction for the hepatologists worldwide that endogenous alcohol may play important role in the development of non–alcoholic fatty liver disease. The closed relationship among endogenous alcohol and liver,intestine,intestinal flora and non–alcoholic fatty liver disease provides a new sight to explain the pathogenesis of non–alcoholic fatty liver diseases.

Key words: Non–alcoholic fatty liver diseases, Endogenous alcohol, Intestinal flora