血管介入治疗肝癌栓塞材料临床进展

doi:10.3969/j.issn.1672-5069.2015.02.034

摘要/Abstract

摘要： 对于不能行手术切除治疗的肝癌患者,血管介入治疗发挥了重要的作用,而介入栓塞材料的选择以及血管栓塞是否完全影响着血管介入治疗肝癌的效果。本文将常用的血管介入治疗栓塞材料的特点及临床应用作以介绍。

Abstract: Vascular inteventional therapy has played an important role in patients with unresectable primary liver cancer（PLC）,while the effect of vascular interventional therapy is closely related to the choice of embolic materials. We reviewed the characteristics and the clinical application of common embolic materials used in vascular inteventional therapy.

Key words: Primary liver cancer, Vascular interventional therapy, Embolic materials

刘卉, 陈东风. 血管介入治疗肝癌栓塞材料临床进展[J]. 实用肝脏病杂志, 2015, 18(3): 333-336.

Liu Hui, Chen dongfeng. Improvement of embolic materials in vascular inteventional therapy of patients with primary liver cancer[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(3): 333-336.

参考文献

[1] 张跃伟. 微创介入治疗肝癌对机体免疫功能影响的研究现状与展望. 实用肝脏病杂志,2014,17（3）:231-233.
[2] Sergio A,Cristofori C,Cardin R,et.al. Transcatheter arterial chemoembolzation in hepatocellular carcinoma:the role of angiogenesis and invasiveness. Am J Gastroenterol,2008,103:914-921. [3] 赵建农.肝癌介入治疗的基本原理.中华肝脏病杂志,2005,13（10）：784.
[4] 黄兢,杨维竹,江娜,等. 经皮门静脉栓塞治疗肝癌的临床应用.介入放射学杂志,2006,15（11）:73-81.
[5] Norihiro I,Masatoshi I. Transarterial chemoembolization for hepatocellular carcinoma:A review of techniques. World J Hepatol, 2014,6（12）:844-850.
[6] Soulen MC. Chemoembolization of hepatic malignancies.Oncol Huntingt,1994,8:77.
[7] Nararuma K. Studies on anticancer treatment with an oil anticancer drug injected into the lighted feeding hepatic artery for liver cance. Cancer,1983,52（11）：2193.
[8] 陈少骥,高敏. 碘化油在肝癌介入治疗中的作用. 介入放射学杂志,1996,5（1）：56-59.
[9] 中国抗癌协会肝癌专业委员会. PLC规范化诊治的专家共识.2009,29（4）：297-304.
[10] 杜卓,邝婉容,徐愉林. 碘化油在医药领域的研究进展. 国际医药卫生导报,2014,20（14）:2027-2030.
[11] Takayasu K,Arii S,Ikai I,et a1. Overall survival after transarterial lipiodol in fusion chemotherapy with or without embolization for unresectable hepatoeellular carcinoma：propen sity score analysis.Am J Roentgenol,2010,19（4）：830-837.
[12] 孙伟,王永涛,史仲华,等. 海藻酸钠微球联合碘化油栓塞治疗原发性肝癌的疗效分析. 中国医学影像学杂志,2012,20（8）:631-634.
[13] 史仲华.海藻酸钠微球栓塞肝脏肿瘤的临床应用.中国肿瘤临床,2007,34（1）：38-44.
[14] 杨建东,孔曼,黄希芬,等.应用海藻酸钠微球联合碘油经导管肝动脉化疗栓塞治疗肝癌.中国介入影像与治疗学,2010,7（3）：225-227.
[15] Vogl TJ,Naguib NN,Nour-Eldin NE,et al. Review on transarterial chemoembolization in hepatocellular carcinoma:palliative,combined,neoadjuvant,bridging,and symptomatic in dications. Eur J Radiol,2009,72（3）:505-516.
[16] Stampfl U,Stampfl S,Bellemann N,et al.Experimental liver embolization with four different spherical embolic materials：impact on inflammatory tissue and foreign body reaction. Cardiovasc Interv Radiol,2009,32：303-312.
[17] 王磊,宋卫华,龚少娟. Embosphere微球化疗栓塞治疗中晚期肝癌的临床疗效的前瞻性研究. 肝胆外科杂志,2013,21（5）:329-333.
[18] Kerr DJ. Microparticu1ate drug delivery systems as an adjunct to cancer treatment.Cancer Drug Deliv,1987,4（1）：55-61.
[19] Lewis AL,Gonzalez MV,Leppard SW,et al.Dixibrybucin eluting beads-1:effects of drug loading on bead characteristics and drug distribution.J Mater Sci Mater Med,2007,18（9）:1691-1699.
[20] Varela M,Real MI,Burrel M,et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads：efficacy and doxorubicin pharmacokinetics. J Hepatol,2007,46（3）：474-481.
[21] Fiorentini G,Aliberti C,Tilli M,et al.Intra-arterial infusion of irinotecan-loaded drug-eluting beads（DEBIRI）versus intravenous therapy（FOLFIRI）for hepatic metastases from colorectal cancer：final results of a phase III study. Anticancer Res,2012,32（4）:1387-1395.
[22] Dreher MR,Sharmakv K,Woods DL,et al. Radiopaque drug-eluting beads for transcatheter embolotherpy：experimental study of drug penetration and coverage in swine. J Vasc Interv Radiol,2012,23（2）：257-264.
[23] Dawson LA,Ten Haken RK. Partial volume tolerance of the liver to radiation. Semin Radiat Oncol,2005,15（4）:279-283.
[24] Nosher JL,Ohman-Strickland PA,Jabbour S,et al. Changes in liver and spleen volumes and liver function after radioembolization with yttrium-90 resin microspheres. J Vasc Interv Radiol,2011,22:1706-1713.
[25] 张龙,李楠;石洁. 原发性肝癌伴门静脉癌栓放射治疗的现状及展望. 中华外科肝胆杂志,2014,20（6）：476-480.
[26] Marelli L,Shusang V,Buscombe JR,et al.Transarterial injection of（131）I-lipiodol,compared with chemoembolization,in the treatment of unresectable hepatocellular cancer. J Nucl Med,2009,50（6）:871-877.
[27] Zhang FJ,Li CX,Jiao DC,et al. CT guided 125Iodine seed implantation for portal vein tumor thrombus in primary hepatocellular carcinoma. Chin Med J（Engl）,2008,121（23）:2410-2414.
[28] 朱蓝玉,雍娴婷,迟庆,等. 载药磁性纳米微粒靶向治疗恶性肿瘤的研究与临床应用. 中国医药科学,2011,1（19）：25-27.
[29] Goodwin S,Peterson C,Hoh C,et al.Targeting and retention of magnetic targeted carriers enhcemeing intra-artrial chemotherapy. J Magnest Magnet Mater,1999,194（1）:132-139.
[30] Fricker J.Drugs with a magnetic at traction to tumors. Drug Discov Today,2001,6（8）：38-71.
[31] 张旭平,易玉海,金鹏,等. 超微化白芨粉混悬液栓塞治疗原发性肝癌的临床效果. 实用医药杂志,2006,13（3）：640-641.
[32] 吴万垠. 莪术油微球经肝动脉灌注治疗原发性肝癌.上海中医药杂志,2004,38（4）：3-6.
[33] Yu SC,Hui EP,Wong J,et al.Transarterial ethanol ablatin of hepatolellular carcinoma with lipiodol ethanol mixture:phase II study. J Vasc Interv Radiol,2008,19（1）:95-103.
[34] 孙成建,王松,李子祥.原发性肝癌的介人治疗. 山东医药,2005,45（10）:64-66.