关键词: 肝硬化, 急性肾损伤, 危险因素, 单因素分析, Logistic回归分析

Abstract: ObjectiveTo study the risk factors for acute kidney injury in patients with decompensated liver cirrhosis. Methods Relevant clinical data of 254 patients with decompensated liver cirrhosis and ascites were retrospectively analyzed. The patients were divided into observation group with serum creatinine levels beyond the upper limit of normal（n=135） and control group with normal serum creatinine（n=119）. The risk factors for acute kidney injury were analyzed by univariate and multivariate analysis methods. ResultsThe incidences of hepatic encephalopathy were 50.4% in observation group and 10.1% in control group (P<0.01）;the incidences of spontaneous bacteria peritonitis （SBP） and infection in other sites were 70.4% and 32.6% in observation group,significantly higher than in patients in control group （41.2% and 19.3%,respectively,P<0.01）;the serum sodium,total bilirubin levels and white blood cell counts were 128 mmol/L, 391.8 μmol/L and 9.33×10⁹/L,respectively,in observation group, which were significantly different as compared to those in control group （136.8 mmol/L,51.58 μmol/L and 3.9×10⁹/L,respectively,P<0.01）;the plasma prothrombin time activity（PTA） were （34.2±17.3）% in observation group and （52.1±16.1）% in control group （P<0.01）. logistic regression analysis showed that hepatic encephalopathy,hyponatremia,total bilirubin,PTA,white blood cell counts were all independent risk factors for acute kidney injury in patients with decompensated cirrhosis （P<0.05）. Conclusion Patients with decompensated cirrhosis are under high-risk of acute kidney injury when hepatic encephalopathy,infection,hyponatremia,hyper-bilirubinemia or serious coagulopathy occur.

Key words: Liver cirrhosis, Acute kidney injury, Risk factors, Univariate analysis, Logistic regre