重症酒精性肝炎与肝移植

doi:10.3969/j.issn.1672-5069.2014.01.004

实用肝脏病杂志 ›› 2014, Vol. 17 ›› Issue (1): 12-14.doi: 10.3969/j.issn.1672-5069.2014.01.004

重症酒精性肝炎与肝移植

张敏

100039 北京市解放军第302医院肝移植研究中心/内科

收稿日期:2013-10-07 出版日期:2014-02-28 发布日期:2016-04-11
作者简介:张敏,女,42岁,医学博士,副主任医师。主要从事肝病与肝移植后管理的临床与基础研究。E-mail：gcmw2001@163.com

Severe alcoholic hepatitis and liver transplantation

Zhang Min

Center of Liver Transplantation,302nd Hospital,Beijing 100039

Received:2013-10-07 Online:2014-02-28 Published:2016-04-11

摘要/Abstract

摘要： 饮酒相关性肝病包括酒精性脂肪肝（alcoholic steatosis,AS）、酒精性肝炎（alcoholic hepatitis,AH）和酒精性肝硬化（alcoholic liver cirrhosis,ALC）等一组疾病^[1]。重症酒精性肝炎（severe alcoholic hepatitis, SAH）是AH的严重类型,可发生于无肝病史的人群（急性酒精中毒）,也可发生在AS或ALC患者。主要表现为发热、肝脏肿大伴触痛、血清胆红素和外周血白细胞显著升高,可伴有慢性肝损伤和门脉高压的表现。SAH 患者Maddrey 判别函数（Maddrey discriminant function,MDF）[MDF=4.6x（PT-正常对照）+TBIL（mg/dl）]通常≥32 分,极易并发感染和多器官功能衰竭^[2]。即使积极治疗,SAH 患者近期病死率仍可高达35%至50%^[3]。

关键词: 重症酒精性肝炎, 肝移植, 复饮管理

Key words: Severe alcoholic hepatitis, Liver transplantation, Spree, Relapse

张敏. 重症酒精性肝炎与肝移植[J]. 实用肝脏病杂志, 2014, 17(1): 12-14.

Zhang Min. Severe alcoholic hepatitis and liver transplantation[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2014, 17(1): 12-14.

参考文献

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[13] Cuadrado A. Alcohol recidivism impairs long-term patient survival after orthotopic liver transplantation for alcoholic liver disease. Liver Transplant,2005,11：420-426.
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重症酒精性肝炎与肝移植

Severe alcoholic hepatitis and liver transplantation

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