[1] Fire A,Xu S,Montgomery MK,et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature,1998,391,（6669）:806-811.
[2] Feitelson MA,Sun B,Satiroglu Tufan NL,et al. Genetic mechanisms of hepatocarcinogenesis. Oncogene,2002,21（16）:2593-2604.
[3] Guo S,Kemphues KJ. Par-1,a gene required for establishing polarity in C. elegans embryos,encodes a putative Ser/Thr kinase that is asymmetrically distributed.Cell,1995,81（4）:611-620.
[4] Aravin AA,Klenov MS,Vagin VV,et al. Role of double-stranded RNA in eukaryotic gene silencing. Mol Biol（Mosk）, 2002,36（2）:240-251.
[5] Sui G,Soohoo C,Affarel B,et al. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA,2002,99（8）:5515-5520.
[6] Elbashir SM,Harborth J,Lendeckel W,et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cell. Nature,2001,411（6836）:494-498.
[7] Tobe K,Suzuki R,Aoyama M,et al. Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2（-/-） mouse liver.J Biol Chem,2001,276,42）:38337-38340.
[8] Nykanen A,Haley B,Zamore PD. ATP requirements and small interferings RNA structure in the RNA interference pathway. Cell,2001,107（3）:309.
[9] Mcmanus MT,Sharp PA. Gene silencing in mammals by small interfering RNAs. Nature Rev Genet,2002,3（10）:737-747.
[10] Elbashir SM,Lendecked W,Tuschl T. RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes,2001,15（2）:188.
[11] Bernstein E,Caudy AA,Hammond SM,et al. Role for a bidentate eibonuclease in the initiation srep of RNA interference. Nature,2001,409（6818）:363-366.
[12] Semizarov D,Frost L,Sarthy A,et al. Specificity of short interfering RNA determined through gene expression signatures. Proc Natl Acad Sci USA,2003,100（11）:6347-6352.
[13] Hannon GJ,Rossi JJ. Unlocking the potential of the human genome with RNA interference. Nature,2004,431（7006）:371-378.
[14] Lieber CS,Leo MA,Mak KM,et al. Acarbose attenuates experimental non-alcoholic steatohepatitis. Biochem Biophys Res Commun,2004,315（3）:699-703.
[15] Plasma C,Soardo G,Esposito W,et al. Plasma adiponectin is decreased in nonalcoholic fatty liver disease. Eur J Endocrinol,2005,152（1）:113-118.
[16] Yin JQ,Gao J,Shao R,et al. siRNA agents inhibit oncogene expression and attenuate human tumor cell growth. J Exp Ther Oncol,2003,3（4）:194-204.
[17] Li J,Shen F,Wu D,et al. Expression level of Bcl-XL critically affects sensitivity of hepatocellular carcinoma cells to LIGHT-enhanced and interferon- gamma-induced apoptosis. Oncol Rep,2007,17（5）:1067-1075.
[18] Wu X,Fan J,Wang X,et al. Downregulation of CCR1 inhibits human hepatocellular carcinoma cell invasion. Biochem Biophys Res Commun,2007,355（4）:866-871.
[19] Coy JF,Dresslerd,Wilde J,et al. Mutations in the transketolase-like gene TKTL1:clinical implications for neurodegenerative diseases,diabetes and cancer. Clin Lab,2005,51（5-6）:257-273.
[20] Zhang S,Yang JH,Guo CK,et al. Gene Silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. Cancer Lett,2007,253（1）:108-114.
[21] Sun T,Zhao N,Zhao XL,et al. Expression and functional significance of twist1 in hepatocellular carcinoma:Its role in vasculogenic mimicry. Hepatology,2009,50（12）:1-12.
[22] Salvi A,Arici B,Portolani N,et al. In vitro c-met inhibition by antisense RNA and plasmid-based RNAi down-modulates migration and invasion of hepatocellular carcinima cells. Int J Oncol,2007,31（2）:451-460.
[23] 陆彬彬,殷咏梅,王朝霞,等. 人血管内皮生长因子SHRNA真核表达载体对肝癌细胞系SMMC-7721的增殖影响. 南京医科大学学报（自然科学版）,2006,26（6）:403-406.
[24] 朱晓群,叶青海,雷科峰,等. 特异性小干扰性RNA降低骨桥蛋白基因表达对肝癌细胞侵袭性的影响. 中华肿瘤杂志,2006,28,6）:404-407.
[25] 陈钟,陈小建,常仁安,等. RNA干扰PLK1基因表达对肝癌细胞增殖的影响. 中国普通外科杂志,2010,9（19）:1001-1004.
[26] 檀英霞,刘志玄,李素波,等. RNA干扰对肝素酶在肝癌细胞中表达及其肿瘤生长抑制的作用.世界华人消化杂志,2008 16（2）:138-143.
[27] 赵岳,徐凯成,张燕菊,等. RNA干扰抑制人肝癌细胞N-RAS基因表达的研究. 中国实验诊断学,2010,14（2）:177-179
[28] Luo M,Liu YJ,Xia LM,et al. Very low density lipoprotein receptor subtype II silencing by RNA interference inhibits cell proliferation in hepatoma cell lines. Hepatogatroenterology,2010,57（101）:882-890.
[29] Huang S,Zhang F,Miao L,et al. Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells. Oncol Rep,2008,20（5）:1053-1059.
[30] 李俊,孙倍成,邓蕾,等. 针对人IKKα、IKKβ基因RNA干扰慢病毒质粒的构建及其对人肝癌细胞生长的影响. 江苏医药,2009,35（1）:75-77. |
