上皮间质转化在肝纤维化和肝细胞癌发病中的作用研究进展*

doi:10.3969/j.issn.1672-5069.2011.06.039

实用肝脏病杂志 ›› 2011, Vol. 14 ›› Issue (6): 475-476.doi: 10.3969/j.issn.1672-5069.2011.06.039

上皮间质转化在肝纤维化和肝细胞癌发病中的作用研究进展^*

吴冬综述,柯爱武,郭传勇审校

200072 上海市同济大学附属第十人民医院消化科

收稿日期:2011-06-03 出版日期:2011-12-15 发布日期:2016-04-14
通讯作者: 郭传勇，E-mail: guochuanyong@sina.com
作者简介:吴冬男，25岁，博士研究生。E-mail:wudong65@163.com
基金资助:
上海市自然科学基金资助项目（No.11ZR1428300）

Received:2011-06-03 Online:2011-12-15 Published:2016-04-14

摘要/Abstract

摘要： 上皮间质转化（EMT）是胚胎发育中的正常生理过程，但在成年个体中，EMT则与疾病的发生有关。肝脏上皮细胞可能通过EMT过程参与了肝纤维化形成。另外，EMT与肝癌的侵袭转移也密切相关。

关键词: 肝纤维化, 肝癌, 上皮间质转化, 分子机制

吴冬,柯爱武,郭传勇. 上皮间质转化在肝纤维化和肝细胞癌发病中的作用研究进展^*[J]. 实用肝脏病杂志, 2011, 14(6): 475-476.

[1] SAVAGNER P.The epithelial-mesenchymal transition（EMT） phenomenon[J]. Ann Oncol，2010，21（7）:89-92.
[2] ARNOUX V，NASSOUR M，L’HELGOUALC’H A，et al.Erk5 controls slug expression and keratinocyte activation during wound healing[J]. Mol Biol Cell，2008，19:4738-4749.
[3] SAVAGNER P.Leaving the neighborhood:molecular mechanisms involved during epithelial-mesenebymal transition[J]. Bioessays， 2001，23:912-923.
[4] THIERY JP，ACLOQUE H，HUANG RY，et al.Epithelial-mesenchymal transitions in development and disease[J]. Cell，2009，139（5）:871-890.
[5] YANG J，LIU Y.Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis[J]. Am J Pathol，2001，159:1465-1475.
[6] WILLIS BC， DUBOIS RM，BOROK Z.Epithelial origin of myofibroblasts during fibrosis in the lung[J]. Proc Am Thorac Soc，2006，3（4）:377-382.
[7] KAIMORI A，POTTER J，KAIMORI JY，et al.Transforming growth factor-β induces an epithelial-tomesenchymal transition state in mouse hepatocytes in vitro[J]. J Biol Chem，2007，282:22089-22101.
[8] ZEISBERG M，YANG C，MARTINO M，et al.Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition[J]. J Biol Chem，2007，282:23337-23347.
[9] NITTA T，KIM JS，MOHUCZY D，et al.Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways[J]. Hepatology,2008,48:909-919.
[10] XIA JL，DAI C，MICHALOPOULOS GK，et al.Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation[J]. Am J Pathol，2006，168（5）：1500-1512.
[11] WELLS RG.The epithelial-to-mesenchymal transition in liver fibrosis：here today，gone tomorrow[J]. Hepatology，2010，51:737-740.
[12] ROBERTSON H，KIRBY JA，YIP WW，et al.Biliary epithelial-mesenchymal transition in post-transplantation recurrence of primary biliary cirrhosis[J]. Hepatology，2007，45:977-981.
[13] SCHOLTEN D，SCHOLTEN A，BRENNER DA，et al.Epithelialto-mesenchymal transition （EMT） in cholangiocytes does not contribute to liver fibrosis[J]. Hepatology，2009，50（Suppl）:818A.
[14] LIM YS，KIM KA，JUNG JO，et al.Modulation of cytokeratin expression during in vitro cultivation of human hepatic stellate cells:evidence of trans-differentiation from epithelial to mesenchymal phenotype[J]. Histochem Cell Biol，2002，118:127-136.
[15] LIM YS，HC LEE，HS LEE.Switch of cadherin expression from E-to N-type during the activation of rat hepatic stellate cells[J]. Histochem Cell Biol，2007，127（2）:149-160.
[16] VAN ZIJL F，ZULEHNER G，PETZ M.Epithelial-mesenchymal transition in hepatocellular carcinoma[J]. Future Oncol，2009，5（8）:1169-1179.
[17] ZHAI B，YAN HX，LIU SQ，et al.Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas[J]. World J Gastroenterol，2008，14:5665-5673.
[18] FRANSVEA E，ANGELOTTI U，ANTONACI S，et al.Blocking transforming growth factor-β up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells[J]. Hepatology，2008，47:1557-1566.
[19] YANG MH，CHEN CL，CHAU GY，et al.Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma[J]. Hepatology，2009，50：1464-1474.
[20] LEE TK，POON RT，YUEN AP，et al.Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition[J]. Clin Cancer Res，2006，12:5369-5376.
[21] JIAO W，MIYAZAKI K，KITAJIMA Y.Inverse correlation between Ecadherin and snail expression in hepatocellular carcinoma cell lines in vitro and in vivo[J]. Br J Cancer，2002，86:98-101.
[22] MIYOSHI A，KITAJIMA Y，SUMI K，et al.Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells[J]. Br J Cancer,2004，90:126-1273.
[23] GIANNELLI G，BERGAMINI C，FRANSVEA E，et al.Antonaci S.Laminin-5 with transforming growth factor-β1 induces epithelial to mesenchymal transition in hepatocellular carcinoma[J]. Gastroenterology，2005，129:1375-1383.
[24] RIOU P，SAFFROY R，CHENAILLER C，et al.Expression of T-cadherin in tumor cells influences invasive potential of human hepatocellular carcinoma[J]. FASEB J，2006，20:2291-2301.
[25] TSAI WC，HSU PW，LAI TC，et al.MicroRNA-122，a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma[J]. Hepatology，2009，49:1571-1582.
[26] BATTAGLIA S，BENZOUBIR N，NOBILET S，et al.Liver cancer-derived hepatitis C virus core proteins shift TGF-β responses from tumor suppression to epithelial-mesenchymal transition[J]. PLoS One，2009，4:e4355.
[27] LEE TK，MAN K，POON RT，et al.Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition[J]. Cancer Res，2006，66:9948-9956.
[28] FUCHS BC，FUJII T，DORFMAN JD，et al.Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells[J]. Cancer Res，2008，68:2391-2399.

上皮间质转化在肝纤维化和肝细胞癌发病中的作用研究进展^*

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	. 肝纤维化诊断及治疗共识（2019年）[J]. 实用肝脏病杂志, 2019, 22(6): 793-803.
[2]	闵峰, 黄文琪, 吴卫兵, 张丽, 范荣华. 慢性乙型肝炎患者血清脂肪细胞因子水平变化及其临床意义^*[J]. 实用肝脏病杂志, 2019, 22(6): 824-827.
[3]	吴海义, 陈建新. 四种诊断模型诊断乙型肝炎病毒携带者肝纤维化的效能分析^*[J]. 实用肝脏病杂志, 2019, 22(6): 832-835.
[4]	陈梅梅, 段晓燕, 曹海霞, 丁雯瑾. 复方鳖甲软肝片治疗原发性胆汁性肝硬化患者疗效分析^*[J]. 实用肝脏病杂志, 2019, 22(6): 880-883.
[5]	邢昊, 韩骏, 杨田. 应用血清PIVKA-II诊断肝细胞癌研究进展^*[J]. 实用肝脏病杂志, 2019, 22(6): 934-937.
[6]	高伟, 侯勇. 肝脏硬度值检测诊断慢性乙型肝炎患者肝组织纤维化的效能分析*[J]. 实用肝脏病杂志, 2019, 22(5): 652-655.
[7]	刘杏, 赵树立, 张殿隆. 七氟烷吸入时机对肝脏部分切除术患者肝脏缺血再灌注损伤的影响*[J]. 实用肝脏病杂志, 2019, 22(5): 728-731.
[8]	裴颖, 黄峰, 殷宏振, 郭化磊. 去甲斑蝥酸钠对肝癌异位移植瘤小鼠肠道微生态的影响初探*[J]. 实用肝脏病杂志, 2019, 22(4): 486-489.
[9]	程华, 鞠辉, 宋德顺, 李伟. 慢性乙型肝炎患者血清血管生成素样蛋白2和高尔基体蛋白73水平变化及其诊断显著肝纤维化的效能分析^*[J]. 实用肝脏病杂志, 2019, 22(4): 494-497.
[10]	余英芳, 温生宝. 应用磁共振DWI单指数、双指数和拉伸指数模型参数评估慢性乙型肝炎患者肝纤维化程度效能研究^*[J]. 实用肝脏病杂志, 2019, 22(4): 502-505.
[11]	张亚飞, 叶珺, 谢琴秀, 邹桂舟, 李家斌, 李旭, 张振华. 不同医院无创性肝纤维化指标预测慢性乙型肝炎患者肝纤维化效能差异分析^*[J]. 实用肝脏病杂志, 2019, 22(4): 510-513.
[12]	戴青云, 王润东, 荚卫东. 术前预后营养指数评估肝细胞癌患者肝切除术后早期肿瘤复发价值探讨^*[J]. 实用肝脏病杂志, 2019, 22(4): 561-564.
[13]	崔发强, 李涛, 王铮, 陈青. 原发性肝癌患者外周血KRAS基因水平及其对西妥昔单克隆抗体治疗疗效的影响[J]. 实用肝脏病杂志, 2019, 22(4): 565-568.
[14]	周丽云, 李校天, 李丽, 杨俊超. 1,25（OH）₂D₃通过调节miR-146a水平抑制大鼠肝纤维化的体内和体外观察[J]. 实用肝脏病杂志, 2019, 22(3): 333-336.
[15]	赵晓光, 史玉洁. 应用还原型谷胱甘肽预防处理接受TACE治疗的中晚期原发性肝癌患者对肝功能的影响[J]. 实用肝脏病杂志, 2019, 22(3): 425-428.