儿童EB病毒感染相关肝损伤研究进展

doi:10.3969/j.issn.1672-5069.2024.02.040

摘要/Abstract

摘要： EB病毒是人疱疹病毒家族成员之一, 可引起很多疾病。儿童EB病毒感染性疾病多伴有肝损伤, 通常表现为轻至中度肝功能异常, 重者可发展为肝衰竭, 甚至死亡。大多数急性感染患儿经对症支持治疗后恢复正常, 而慢性感染或移植术后感染, 在积极治疗原发病的同时, 需进行免疫调节、化疗和骨髓移植等治疗。本文对儿童EB病毒感染相关肝损伤的流行病学、发病机制、诊疗和预后进行综述, 为临床诊治提供参考。

关键词: EB病毒感染, 肝损伤, 儿童

Abstract: The Epstein-Barr virus (EBV) is one of the members of the human herpesvirus family, which might cause many diseases. The children with EBV infection often have liver injury, which is usually manifested as mild to moderate liver dysfunctions. In severe cases, it can develop into liver failure and even lead to death. Most children with acute EB viral infection recover after supportive treatment. However, in cases of chronic infection or post-transplant infection, the immunomodulatory therapy, chemotherapy, and even bone marrow transplantation may be required in addition to actively management of the underlying diseases. In this review, we describes the comprehensive updates of the epidemiology, pathogenesis, diagnosis, treatment and prognosis of children with liver injury associated with EBV infection.

Key words: Epstein-Barr viral infection, Liver injury, Children

马子坤, 赵新颜. 儿童EB病毒感染相关肝损伤研究进展[J]. 实用肝脏病杂志, 2024, 27(2): 317-320.

Ma Zikun, Zhao Xinyan. Epstein-Barr virus infection-associated liver injury in children[J]. Journal of Practical Hepatology, 2024, 27(2): 317-320.

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