MicroRNAs作为药物性肝损伤生物标记物研究进展

doi:10.3969/j.issn.1672-5069.2023.05.040

摘要/Abstract

摘要： 药物性肝损伤(DILI)是全球卫生健康领域的重要挑战和阻碍新药研发的主要障碍之一。DILI缺乏特异性的诊断手段和治疗措施,目前主要依赖早期诊断和对症治疗。本文综述了近年来MicroRNAs作为DILI生物标记物研究取得的重要进展,以期加深对DILI诊断标记物的认识。

关键词: 药物性肝损伤, 微小RNAs, 生物标记物, 诊断

Abstract: Drug-induced liver injury (DILI) is an important challenge to deal with. DILI lacks specific diagnostic parameters and treatment measures, and mainly depends on early diagnosis and supporting treatment. In this article, we reviewed the important achievements on microRNAs study as biomarkers for DILI diagnosis in recent years.

Key words: Drug-induced liver injury, MicroRNAs, Biomarkers, Diagnosis

桂芬芬, 周杰斌. MicroRNAs作为药物性肝损伤生物标记物研究进展[J]. 实用肝脏病杂志, 2023, 26(5): 761-764.

Gui Fenfen, Zhou Jiebin. Micro RNAs as biomarkers in patients with drug-induced liver injury[J]. Journal of Practical Hepatology, 2023, 26(5): 761-764.

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