超声引导下无水乙醇与聚桂醇硬化治疗单纯性肝囊肿患者效果比较研究*

doi:10.3969/j.issn.1672-5069.2023.03.032

实用肝脏病杂志 ›› 2023, Vol. 26 ›› Issue (3): 428-431.doi: 10.3969/j.issn.1672-5069.2023.03.032

超声引导下无水乙醇与聚桂醇硬化治疗单纯性肝囊肿患者效果比较研究^*

张琼, 陈士颖, 夏维

436000 湖北省鄂州市鄂州中医医院超声影像科(张琼);鄂州中心医院超声影像科(陈士颖);华中科技大学同济医学院附属同济医院麻醉科(夏维)

收稿日期:2022-06-29 出版日期:2023-05-10 发布日期:2023-05-08
通讯作者: 夏维,E-mail:jamesxia@163.com
作者简介:张琼,女,40岁,大学本科,主治医师。E-mail:zq4393910@163.com
基金资助:
^*湖北省卫生健康委转化医学研究项目(编号:WJ2021ZH0003)

Comparison of anhydrous ethanol and lauromacrogol sclerotherapy under ultrasound guidance in the treatment of patients with simple hepatic cysts

Zhang Qiong, Chen Shiying, Xia Wei

Department of Ultrasound, Ezhou Hospital of Traditional Chinese Medicine, Ezhou 436000, Hubei Province, China

Received:2022-06-29 Online:2023-05-10 Published:2023-05-08

摘要/Abstract

摘要： 目的比较应用无水乙醇或聚桂醇硬化治疗单纯性肝囊肿患者的效果。方法 2019年1月～2021年10月我院收治的97例单纯性肝囊肿患者,被随机分为两组,在超声引导下分别应用无水乙醇(n=48)或聚桂醇(n=49)行硬化治疗,随访6个月。采用ELISA法检测血清C反应蛋白(CRP)、皮质醇(Cor)和去甲肾上腺素(NE)水平。结果在术后6个月,聚桂醇组和无水乙醇组治疗有效率分别为98.0%和98.0%,无显著性差异(P＞0.05);术后2 d,聚桂醇组白细胞、红细胞和血小板计数分别为(4.9±0.9)×10⁹/L、(4.4±0.9)×10¹²/L和(118.8±16.5)×10⁹/L,与无水乙醇组【分别为(5.1±1.1)×10⁹/L、(4.6±0.7)×10¹²/L和(120.5±22.4)×10⁹/L,P＞0.05】比,差异无显著性统计学意义;聚桂醇组血清Cor、CRP和NE水平分别为(231.6±34.5)ng/mL、(11.5±1.7)mg/L和(257.6±31.6)ng/mL,与无水乙醇组【分别为(233.7±30.6)ng/mL、(12.0±2.0)mg/L和(260.2±33.5)ng/mL,P＞0.05】比,差异也无统计学意义;术后,聚桂醇组腹胀腹痛、恶心呕吐、醉酒样反应和针道出血发生率分别为18.4%、24.5%、0.0%和2.0%,显著低于无水乙醇组的43.8%、52.1%、22.9%和16.7%(P＜0.05)。结论在超声引导下应用无水乙醇或聚桂醇硬化治疗单纯性肝囊肿患者均安全有效,但相对于无水乙醇,应用聚桂醇的不良反应更轻。

关键词: 单纯性肝囊肿, 超声引导, 聚桂醇, 无水乙醇, 硬化治疗

Abstract: Objective The aim of this study was to compare the efficacy of anhydrous ethanol and lauromacrogol sclerotherapy under ultrasound (US) guidance in the treatment of patients with simple hepatic cysts (SHC). Methods A total of 97 patients with SHC were encountered in our hospital between January 2019 and October 2021, and were randomly divided into two groups, receiving lauromacrogol (n=49) or anhydrous ethanol (n=48) for sclerotherapy under US guidance. All the patients were followed-up for six months. Serum C-reaction protein (CRP), cortisol (Cor) and norepinephrine (NE) levels were detected by ELISA. Results At the end of six month follow-up, the effective rates in the two groups were not significantly different (98.0% vs. 98.0%, P＞0.05); two days after operation, the peripheral white blood cell counts, red blood cell counts and platelet counts in patients with lauromacrogol sclerotherapy were(4.9±0.9)×10⁹/L, (4.4±0.9)×10¹²/L and (118.8±16.5)×10⁹/L, not significantly different as compared to [(5.1±1.1)×10⁹/L, (4.6±0.7)×10¹²/L and (120.5±22.4)×10⁹/L, respectively, P＞0.05] in patients with ethanol sclerotherapy; serum Cor, CRP and NE levels in lauromacrogol-treated patients were (231.6±34.5)ng/mL, (11.5±1.7) mg/L and (257.6±31.6)ng/mL, also not significantly different compared to [(233.7±30.6)ng/mL,(12.0±2.0)mg/L and (260.2±33.5)ng/mL, respectively, P＞0.05] in ethanol-treated patients; after operation, the incidence rates of abdominal distention and pain, nausea and vomiting, drunkenness response, and needle tract bleeding in lauromacrogol-treated patients were 18.4%, 24.5%, 0.0% and 2.0%, significantly lower than 43.8%, 52.1%, 22.9% and 16.7%(P＜0.05) in ethanol-treated patients. Conclusion The clerotherapy with anhydrous ethanol or lauromacrogol under US-guidance in dealing with patients with SHC is safe and efficacious, and the application of lauromacrogol might have relatively fewer side effects as compared with anhydrous ethanol.

Key words: Simple hepatic cyst, Ultrasound guidance, Anhydrous ethanol, Lauromacrogol, Sclerotherapy

张琼, 陈士颖, 夏维. 超声引导下无水乙醇与聚桂醇硬化治疗单纯性肝囊肿患者效果比较研究^*[J]. 实用肝脏病杂志, 2023, 26(3): 428-431.

Zhang Qiong, Chen Shiying, Xia Wei. Comparison of anhydrous ethanol and lauromacrogol sclerotherapy under ultrasound guidance in the treatment of patients with simple hepatic cysts[J]. Journal of Practical Hepatology, 2023, 26(3): 428-431.

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超声引导下无水乙醇与聚桂醇硬化治疗单纯性肝囊肿患者效果比较研究^*

Comparison of anhydrous ethanol and lauromacrogol sclerotherapy under ultrasound guidance in the treatment of patients with simple hepatic cysts

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