关键词: 肝硬化, 代谢相关脂肪性肝病, 瘦素, 肝功能分级

Abstract: Objective The aim of this study was to investigate the changes of serum leptin level in patients with hepatitis B liver cirrhosis and concomitant metabolic associated fatty liver diseases (MAFLD). Methods The specimen from 186 patients with hepatitis B liver cirrhosis (including 95 cases of Child-Pugh class A, 51 cases of Child-Pugh class B and 40 cases of Child-Pugh class C) as the Sino-French Hepatocellular Carcinoma Project in our hospital were selected, and out of the patients with Child-Pugh class A, 49 patients had, and 46 had not concomitant MAFLD.Serum LP levels were determined by ELISA. The multivariate Logistic analysis was applied to reveal the risk factors for MAFLD occurrence. Results Serum AFP and LP levels in cirrhotics with MAFLD were (2.1±1.3)ln ng/ml and (0.9±1.2)ng/ml, significantly higher than [(1.5±1.1)ln ng/ml and (0.5±1.1)ng/ml, respectively, P＜0.05] in cirrhotics without; the multivariate Logistic regression analysis was performed with the concomitant MAFLD as the dependent variable, the final factors found included serum LP and AFP levels, the risk for MAFLD occurrence increased 2.3 times for every increased 1 unit of serum LP level (P＜0.05, OR=2.3), and the risk for MAFLD increased 1.8 times for every increased 1 unit of serum LP level (P＜0.05, OR=1.8); there was no significant difference respect to serum LP level (P＞0.05), while there was significant differences respect to serum AFP level among cirrhotics with Child-Pugh class A, class B and class C (P<0.05). Conclusion Serum LP levels in patients with hepatitis B liver cirrhosis and concomitant MAFLD increase, but no correlation is found between serum LP levels and the severity of liver cirrhosis, suggesting that the elevated serum LP levels in patients with hepatitis B cirrhosis might be related to the combined metabolic factors.

Key words: Liver cirrhosis, Metabolic associated fatty liver diseases, Leptin, Liver function classification