关键词: 非肝硬化门脉高压, 特发性门脉高压, 非特发性门脉高压, 肝静脉压力梯度, 特征

Abstract: Objective The aim of this study was to summarize the clinical features and hepatic venous pressure gradient (HVPG) changes in patients with noncirrhotic portal hypertension (NCPH).Methods 28 patients with NCPH were admitted to our hospital between January 2017 and December 2019, the HVPG was measured and calculated by Seldinger from right venae jugularis interna, and the liver biopsies were performed.Results The patients with NCPH included 11 cases of idiopathic portal hypertension(IPH) and 17 cases of non-idiopathic portal hypertension (NIPH); the average age in patients with IPH was (40.6±15.8)yr, significantly younger than [(53.0±12.9)yr, P＜0.05] in patients with NIHP; the HVPG in patients with IPH was (9.9±5.2)mmHg, significantly lower than[(14.3±5.1)mmHg, P＜0.05] in patients with NIPH; serum albumin and cholinesterase levels in patients with IPH were (41.4±4.9)g/L and (6411.7±1839.3)U/L, significantly higher than [(33.9±6.1)g/L and (4438.5±1854.0)U/L, respectively, P＜0.05] in patients with NIPH; the incidence of ascites in patients with IPH was much lower than that in patients with NIPH (27.3% vs. 94.1%, P＜0.01); the occurrence of ascites was positively correlated to(r=0.66, P＜0.01), while the gastrointestinal bleeding and varices were not correlated to HVPG level(r=0.193, P=0.324; r=-0.197, P=0.315); the different entities in our series had their unique histopathological manifestations with common pathological features of non-fibrosis.Conclusion The common clinical approaches could differentiate IPH from NIPH in patients with NCPH, and the correct diagnosis might help dealing with them personally and appropriately.

Key words: Non-cirrhotic portal hypertension, Idiopathic portal hypertension, Non-idiopathic portal hypertension, Hepatic venous pressure gradient, Feature