实用肝脏病杂志 ›› 2018, Vol. 21 ›› Issue (5): 749-752.doi: 10.3969/j.issn.1672-5069.2018.05.024

• 肝癌 • 上一篇    下一篇

多排螺旋CT三期增强与3.0T MR多期动态增强扫描诊断肝细胞癌的价值分析*

鲁雪红, 张源, 刘文亚   

  1. 830000乌鲁木齐市 新疆医科大学附属中医医院影像中心(鲁雪红,张源); 第一附属医院影像中心(刘文亚)
  • 收稿日期:2018-01-22 出版日期:2018-09-10 发布日期:2018-09-27
  • 作者简介:鲁雪红,女,43岁,医学硕士,主治医师。主要从事肝脏病影像学诊断研究。E-mail:luhongxuexj@163.com
  • 基金资助:
    新疆医科大学附属中医医院院长基金资助课题(编号:zyy201310)

Diagnostic value of 3.0T multi-phase dynamic magnetic resonance enhanced scan and multi-slice spiral CT three-phase augmentation in patients with hepatocellular carcinoma

Lu Xuehong, Zhang Yuan, Liu Wenya.   

  1. Department of Radiology, Affiliated Chinese Traditional Medicine Hospital, Xinjiang Medical University, Urumuqi 830000,Xinjiang Uygur Autonomous Region,China
  • Received:2018-01-22 Online:2018-09-10 Published:2018-09-27

摘要: 目的 探讨3.0T MR多期动态增强扫描与多排螺旋CT三期增强扫描诊断肝细胞癌的价值。方法 2015年9月~2017年9月我院收治的98例肝占位患者,分别行MRI和CT增强扫描检查,采用Kappa检验分析三名医师诊断评分之间的一致性,采用受试者工作特征曲线(ROC)并计算曲线下面积(AUC)判断影像学检查指标的诊断效能。结果 在98例肝占位患者中,病理学检查诊断HCC 86例,再生结节10例,嗜酸性肉芽肿2例;在86例HCC患者中,存在97个病灶,其中32个病灶<1.0 cm;在32个<1.0 cm的HCC病灶中, MRI动态增强扫描发现31个(96.9%),而多排螺旋CT增强扫描仅发现26个(81.3%,P<0.05),其余65个超过1.0 cm 的病灶均被两种扫描方法发现和诊断;ROC曲线分析发现,MRI动态增强扫描和多排螺旋CT增强扫描诊断HCC的AUC分别为0.962和0.824,两者相比具有显著性差异(t=3.106,P<0.05),MRI动态增强扫描诊断HCC的敏感性、特异性和准确性分别为99.0%、91.0%和96.2%,显著优于多排螺旋CT增强扫描检查(分别为93.8%、72.0%和85.3%,x2=19.587,P<0.05)。结论 3.0T MR多期动态增强扫描能够更清晰地反映HCC病灶的细微形态特点和强化特征,对于诊断小HCC的价值优于CT增强扫描。

关键词: 肝细胞癌, 3.0T 磁共振成像, 多排螺旋CT成像, 动态增强扫描, 诊断

Abstract: Objective To investigate the diagnostic value of 3.0T multi-phase dynamic magnetic resonance (MR) enhanced scan and multi-slice spiral CT three-phase augmentation in patients with hepatocellular carcinoma(HCC). Methods Ninety-eight patients with suspected primary liver cancer were admitted to our hospital between September 2015 and September 2017,and all of them received MR imaging (MRI) and CT scan. Their efficacy of diagnosis was evaluated by histopathological examination. Kappa test was used to analyze the consistency between diagnostic scores by three doctors' determination. The receiver operating characteristic curve (ROC) was used and the area under the curve (AUC) was calculated to determine the diagnostic efficacy of the imaging findings. Results 86 case out of 98 patients were diagnosed with HCC by pathological confirmation. 97 cancerous foci were found in the 86 patients with HCC by imaging check-up, and 32 were less than 1.0 cm;MRI found 31(96.9%),while CT found 26(81.3%,P<0.05) out of the 32 foci <1.0 cm;both MRI and CT found other 65 foci >1.0 cm;kappa test analysis showed that the HCC diagnostic scores by three physicians were consistent with the k=0.77,0.82,0.74(P>0.05);ROC analysis demonstrated that the AUC were 0.962 and 0.824,respectively,(t=3.106,P<0.05) by MRI and CT,with the sensitivity,specificity and accuracy being 99.0%,91.0% and 96.2% by MRI,significantly superior to 93.8%,72.0% and 85.3% by CT scan(x2=19.587,P<0.05). Conclusion The multi-phase dynamic contrast-enhanced 3.0T MR scan could show the fine morphology and enhancement features of HCC lesions,which might has a better diagnostic efficacy in finding small hepatic cancer.

Key words: Hepatocellular carcinoma, 3.0T MR, Multi-slice spiral CT, Dynamic enhanced scan, Diagnosis