关键词: 酒精性脂肪肝, 水飞蓟宾葡甲胺, 多烯磷脂酰胆碱, 疗效

Abstract: Objective To investigate the curative effect of silybin meglumine combined with phosphatidylcholine in treatment of patients with alcoholic fatty liver （AFL）. Methods 164 patients with AFL were recruited in our hospital between October 2014 and October 2015. Patients were randomly divided into two groups, and 82 patients were treated with phosphatidylcholine as control group,and another 82 patients were treated with silybin meglumine combined with phosphatidylcholine as observation group. Indexes of blood lipid,liver function and imaging examination were compared before and after treatment between the two groups. Results At the end of three month treatment,serum total cholesterol,triglyceride,low density lipoprotein cholesterol,alanine aminotransferase,aspartate aminotransferase and glutamyltranspeptidase levels in observation group were（3.8±0.6） mmol/L,（1.3±0.2） mmol/L,（2.3±0.2） mmol/L,（47.3±7.2） U/L,（41.7±8.0） U/L and（46.5±7.3） U/L,respectively,significantly lower than those in the control group [（4.4±0.5） mmol/L,（1.5±0.2） mmol/L,（2.8±0.3） mmol/L,（58.1±12.4） U/L,（55.6±9.9） U/L and（67.8±10.1） U/L,respectively,P<0.01];serum high density lipoprotein cholesterol level in observation group was（1.3±0.2） mmol/L,which was significantly higher than that in the control group[（1.1±0.2） mmol/L,P<0.01];Imaging examination showed that the numbers of severe,moderate,mild fatty liver and normal liver manifestation in observation group were 1 case（1.2%）,11 cases （13.4%）,33 cases （40.2%） and 37 cases（45.1%）,respectively,significantly better than those in the control group [6 cases （7.3%）,19 cases （23.2%）,45 cases （54.9%） and 12 cases （14.6%）,respectively,P<0.01]. Conclusion Silybin meglumine combined with phosphatidylcholine can significantly improve blood lipid and liver function indexes in patients with AFL.

Key words: Alcoholic fatty liver, Silybin meglumine, Phosphatidylcholine, Therapy