内质网应激诱导未折叠蛋白反应干预药物作用研究进展

doi:10.3969/j.issn.1672-5069.2015.01.027

摘要/Abstract

摘要： 内质网应激（ERS）是由于各种原因引起的内质网中出现错误折叠或未折叠蛋白在腔内聚集以及钙离子平衡紊乱的状态。ERS与各种肝病的发病机制密切相关,因此对ERS进行干预将对肝病的预防和治疗提供新的机会。本文介绍了ERS引起的未折叠蛋白反应及其干预药物在肝病的预防和治疗中可能提供的新的靶点。

关键词: 内质网应激, 未折叠蛋白反应, 抑制剂, 基因治疗

Abstract: Endoplasmic reticulum（ER） homeostasis is perturbed by various pathological conditions,and a given new synthesized unfolded proteins might accumulate in the ER and result in endoplasmic reticulum stress（ERS）. ERS is related to the pathogenesis of the various liver diseases,and some scholars believe that the intervention of ERS will provide new choices for prevention and treatment of liver diseases. This paper will review the unfolded protein response due to ERS,which might be the target for medical intervention for liver diseases.

Key words: Endoplasmic reticulum stress, Unfolded protein response, Inhibitor, Gene therapy

郭媛媛, 任锋, 段钟平, 张桓虎. 内质网应激诱导未折叠蛋白反应干预药物作用研究进展[J]. 实用肝脏病杂志, 2015, 18(1): 92-96.

Guo Yuanyuan, Ren Feng, Duan Zhongping, et al. Endoplasmic reticulum stress-induced unfolded protein response in medicine[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(1): 92-96.

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