[1] Lee C H,Chang C J,Lin Y J,et al. Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma. Br J Cancer,2009,100（11）:1765-1770.
[2] Zhou H,Wang H,Zhou D,et al. Hepatitis B virus-associated intrahepatic cholangiocarcinoma and hepatocellular carcinoma may hold common disease process for carcinogenesis. Eur J Cancer,2010,46（6）:1056-1061.
[3] Spee B,Carpino G,Schotanus B A,et al. Characterisation of the liver progenitor cell niche in liver diseases:potential involvement of Wnt and Notch signalling. Gut,2010,59（2）:247-257.
[4] Nelson W J,Nusse R. Convergence of Wnt,beta-catenin, and cadherin pathways. Science,2004,303（5663）:1483-1487.
[5] Clevers H. Wnt/beta-catenin signaling in development and disease. Cell,2006,127（3）:469-480.
[6] Cadigan K M,Liu Y I. Wnt signaling:complexity at the surface. J Cell Sci,2006,119（Pt 3）:395-402.
[7] Logan C Y,Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol,2004,20:781-810.
[8] Lilien J,Balsamo J. The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Curr Opin Cell Biol,2005,17（5）:459-465.
[9] Cheng A S,Lau S S,Chen Y,et al. EZH2-mediated concordant repression of Wnt antagonists promotes beta-catenin-dependent hepatocarcinogenesis. Cancer Res,2011,71（11）:4028-4039.
[10] Wolfe A,Thomas A,Edwards G,et al. Increased activation of the Wnt/beta-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice. J Pharmacol Exp Ther,2011,338（1）:12-21.
[11] Wang X H,Meng X W,Sun X,et al. Wnt/beta-catenin signaling regulates MAPK and Akt1 expression and growth of hepatocellular carcinoma cells. Neoplasma,2011,58（3）:239-244.
[12] Jia Y,Yang Y,Liu S,et al. SOX17 antagonizes WNT/beta-catenin signaling pathway in hepatocellular carcinoma. Epigenetics,2010,5（8）:743-749.
[13] Uematsu S,Higashi T,Nouso K,et al. Altered expression of vascular endothelial growth factor,fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma. J Gastroenterol Hepatol,2005,20（4）:583-588.
[14] Zhang X,Gaspard J P,Chung D C. Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res,2001,61（16）:6050-6054.
[15] Gao C,Guo H,Downey L,et al. Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. Carcinogenesis,2003,24（12）:1871-1878.
[16] Colnot S,Decaens T,Niwa-Kawakita M,et al. Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A,2004,101（49）:17216-17221.
[17] Wu T. Cyclooxygenase-2 in hepatocellular carcinoma. Cancer Treat Rev,2006,32（1）:28-44.
[18] Dempke W,Rie C,Grothey A,et al. Cyclooxygenase-2: a novel target for cancer chemotherapy?J Cancer Res Clin Oncol, 2001,127（7）:411-417.
[19] Sun M H,Han X C,Jia M K,et al. Expressions of inducible nitric oxide synthase and matrix metalloproteinase-9 and their effects on angiogenesis and progression of hepatocellular carcinoma. World J Gastroenterol,2005,11（38）:5931-5937.
[20] Yuzugullu H,Benhaj K,Ozturk N,et al. Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells. Mol Cancer,2009,8:90.
[21] Toyama T,Lee H C,Koga H,et al. Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration. Mol Cancer Res,2010,8（2）:254-265.
[22] Fiuza U M,Arias A M. Cell and molecular biology of Notch. J Endocrinol,2007,194（3）:459-474.
[23] Mazieres J,He B,You L,et al. Wnt signaling in lung cancer. Cancer Lett,2005,222（1）:1-10.
[24] Logeat F,Bessia C,Brou C,et al. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA,1998,95（14）:8108-8112.
[25] Nijjar S S,Crosby H A,Wallace L,et al. Notch receptor expression in adult human liver:a possible role in bile duct formation and hepatic neovascularization. Hepatology,2001,34（6）:1184-1192.
[26] Nam Y,Sliz P,Song L,et al. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell,2006,124（5）:973-983.
[27] Zhou S,Fujimuro M,Hsieh J J,et al. SKIP,a CBF1-associated protein,interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol,2000,20（7）:2400-2410.
[28] Kovall R A. Structures of CSL,Notch and Mastermind proteins: piecing together an active transcription complex. Curr Opin Struct Biol,2007,17（1）:117-127.
[29] Martinez J C,Muller M M,Turley H,et al. Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4（DLL4）in normal and malignant human tissues. Histopathology,2009,54（5）:598-606.
[30] Radtke F,Raj K. The role of Notch in tumorigenesis:oncogene or tumour suppressor? Nat Rev Cancer,2003,3（10）:756-767.
[31] Qi R,An H,Yu Y,et al. Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res,2003,63（23）:8323-8329.
[32] Croquelois A,Blindenbacher A,Terracciano L,et al. Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology,2005,41（3）:487-496.
[33] Ma S,Chan K W,Hu L,et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology,2007,132（7）:2542-2556.
[34] Giovannini C,Lacchini M,Gramantieri L,et al. Notch3 intracellular domain accumulates in HepG2 cell line. Anticancer Res,2006,26（3A）:2123-2127.
[35] Ishimura N,Bronk S F,Gores G J. Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth. Am J Physiol Gastrointest Liver Physiol,2004,287（1）:G88-G95.
[36] Ishii T,Yasuchika K,Suemori H,et al. Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma. Cancer Lett,2010,294（1）:25-34.
[37] Fukutomi T,Zhou Y,Kawai S,et al. Hepatitis C virus core protein stimulates hepatocyte growth:correlation with upregulation of wnt-1 expression. Hepatology,2005,41（5）:1096-1105.
[38] Lee T H,Tai D I,Cheng C J,et al. Enhanced nuclear factor-kappa B-associated Wnt-1 expression in hepatitis B- and C-related hepatocarcinogenesis: identification by functional proteomics. J Biomed Sci,2006,13（1）:27-39.
[39] DeMorrow S,Francis H,Gaudio E,et al. The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. Am J Physiol Gastrointest Liver Physiol,2008,295（6）:G1150-G1158.
[40] Wang M,Xue L,Cao Q,et al. Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma. Neoplasma,2009,56（6）:533-541. |
