实用肝脏病杂志 ›› 2011, Vol. 14 ›› Issue (4): 275-276.doi: 10.3969/j.issn.1672-5069.2011.04.013

• 论著 • 上一篇    下一篇

血浆置换术治疗慢加急性肝衰竭50例

郑三菊,郑化芝,凌红芬,王蕾   

  1. 442000 湖北省十堰市 湖北医药学院附属人民医院
  • 收稿日期:2011-03-22 修回日期:2016-04-15 出版日期:2011-08-10 发布日期:2016-04-15
  • 作者简介:郑三菊 女,40岁,大学专科,护师。主要从事临床护理工作。E-mail:zhengsanju@yahoo.cn

Plasma exchange for patients with acute-on-chronic liver failure: An analysis of 50 cases

ZHENG Sanju,ZHENG Huazhi,LING Hongfen,et al.   

  1. People' Hospitol Affiliated to Hubei Medicine College,Shiyan 442000,Hubei Province,China
  • Received:2011-03-22 Revised:2016-04-15 Online:2011-08-10 Published:2016-04-15

摘要: 目的 探讨血浆置换术治疗慢加急性肝衰竭的效果。方法 50例慢加急性肝衰竭(ACLF)患者在护肝、降酶、退黄等综合治疗的基础上进行血浆置换治疗,观察治疗前后肝功能、凝血功能的变化,比较早、中、晚期患者的疗效。结果 治疗后病人的总胆红素、丙氨酸氨基转移酶、天门冬酸氨基转移酶较治疗前下降(P<0.01),凝血酶原时间缩短(P<0.01),凝血酶原活动度(PTA)升高(P<0.01),临床症状改善;50例患者中32例(64.0%)存活,ACLF早、中、晚期的有效率分别为95.8%、43.8%、20.0%,早期患者的疗效明显优于中期和晚期(P<0.01);治疗中无明显不良反应。结论 血浆置换术治疗慢加急性肝衰竭安全、有效,早期患者疗效更佳。

关键词: 慢加急性肝衰竭, 血浆置换术, 疗效

Abstract: Objective To explore the therapeutic effect of plasma exchange in the treatment of patients with acute-on-chronic liver failure(ACLF). Methods 50 patients with ACLF were treated with plasma exchange on the basis of routine treatment. The hepatic function,coagulation tests and improvements of clinical symptoms were compared. Results After treatment,the patients' total bilirubin,alanine aminotransferase,aspartate aminotransferase,prothrombin time decreased(P<0.01),prothrombin time activity(PTA)increased(P<0.01),and clinical symptoms improved. 32 cases(64.0%)out of the 50 patients survived. The effective rates of early,middle and late stage of ACLF patients were 95.8%,43.8% and 20.0%,respectively. Conclusions Plasma exchange is safe and effective in treatment of patients with ACLF.

Key words: Acute-on-chronic liver failure, Plasma exchange, Therapeutic effect