肝癌边缘CT强化特征与肿瘤新生血管的相关性研究

doi:10.3969/j.issn.1672-5069.2011.02.020

实用肝脏病杂志 ›› 2011, Vol. 14 ›› Issue (2): 138-141.doi: 10.3969/j.issn.1672-5069.2011.02.020

肝癌边缘CT强化特征与肿瘤新生血管的相关性研究

史慧萍,刘晓雨,李冬梅,张伟,刘春雨

161042 黑龙江省齐齐哈尔市齐齐哈尔医学院第一附属医院CT室（史慧萍，李冬梅，张伟，刘春雨）；病理科（刘晓雨）

收稿日期:2010-11-22 修回日期:2016-04-15 出版日期:2011-04-10 发布日期:2016-04-15
作者简介:史慧萍女，42岁，大学本科，主任医师。主要从事胸腹部CT的诊断工作。E-mail:shihuiping1201@yahoo.com.cn

The correlation between CT enhancement patterns and tumor angiogenesis in the edge of hepatocellular carcinoma

SHI Huiping，LIU Xiaoyu，LI Dongmei，et al.

CT Room，Department of Pathology，the First Affiliated Hospital，Qiqihaer Medical College，Qiqihaer 161042

Received:2010-11-22 Revised:2016-04-15 Online:2011-04-10 Published:2016-04-15

摘要/Abstract

摘要： 目的探讨多层螺旋CT双期扫描判断HCC边缘部强化特征与肿瘤新生血管的相关性。方法 38例经手术证实的HCC患者术前行全肝CT平扫及双期增强扫描，观察其边缘部CT强化特点；采用常规病理学检查和免疫组化检测CD34表达。结果 CT平扫发现病灶边缘清楚者，肿瘤以膨胀性生长为主，病理学上肿瘤多有或薄或厚的包膜，而边缘不清肿瘤在病理学上表现为肿瘤浸润性生长；动态增强后发现肿瘤边缘不清或呈高密度者，癌细胞浸润率高，边缘新生血管丰富，转移的危险性大，而呈低密度者癌细胞浸润率低，新生血管较少，转移的可能性小。结论动态CT增强扫描能很好地显示肿瘤边缘的CT强化特点，进而反映肿瘤组织的病理学改变，对临床有较大的诊治指导意义。

关键词: 肝细胞癌, 肿瘤边缘, CD34, 体层摄影术, X线计算机

Abstract: Objective To investigate the correlation between the enhancement characteristics and tumor angiogenesis in the edge of hepatocellular carcinoma. Methods The characteristics of CT enhancement confirmed by preoperative CT scan and contrast CT of hepatic arterial and portal phase were studied in 38 patients with hepatocellular carcinoma. CD34 was detected by immunohistochemistry in the tumor tissues. Results The tumors with clear edge shown on plain CT with thin or thick envelope were in the manner of expansive growth，while the tumors with unclear edge were in invasive growth；there was a higher probability of invasion for tumors with unclear and high-density，and a probable transfer for tumors with rich edge angiogenesis；relatively，there was lower transfer for tumors with low-density and fewer new blood vessels. Conclusion Dynamic enhanced CT scan can show the CT enhancement characteristics of the tumor，which might reflect the pathological changes and have great significance for clinical guidance.

Key words: Hepatocellular carcinoma, CD-34, Pathology, X-ray computed tomography

史慧萍,刘晓雨,李冬梅,张伟,刘春雨. 肝癌边缘CT强化特征与肿瘤新生血管的相关性研究[J]. 实用肝脏病杂志, 2011, 14(2): 138-141.

SHI Huiping，LIU Xiaoyu，LI Dongmei，et al.. The correlation between CT enhancement patterns and tumor angiogenesis in the edge of hepatocellular carcinoma[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2011, 14(2): 138-141.

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肝癌边缘CT强化特征与肿瘤新生血管的相关性研究

The correlation between CT enhancement patterns and tumor angiogenesis in the edge of hepatocellular carcinoma

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