巨大原发性肝癌立体定向放射治疗计划设计

doi:10.3969/j.issn.1672-5069.2011.01.015

实用肝脏病杂志 ›› 2011, Vol. 14 ›› Issue (1): 40-41.doi: 10.3969/j.issn.1672-5069.2011.01.015

巨大原发性肝癌立体定向放射治疗计划设计

钟南保,吕光明,陈忠华,季洪兵

350025 福州市南京军区福州总医院肿瘤放射治疗中心

收稿日期:2010-11-12 出版日期:2011-02-10 发布日期:2016-04-15
通讯作者: 吕光明，E－mail：brightlgming@hotmail.com
作者简介:钟南保男，36岁，医学硕士，从事肿瘤放射治疗研究。E－mail：nbzhong@163.com

The designing of treatment plan for huge primary liver cancer treated by stereotactic radiotherapy

ZHONG Nanbao，LV Guangming，CHEN Zhonghua，et al.

Center of Radiation Oncology，Fuzhou General Hospital，Nanjing Military Command，Fuzhou 350025，China

Received:2010-11-12 Online:2011-02-10 Published:2016-04-15

摘要/Abstract

摘要： 目的探讨巨大原发性肝癌γ射线立体定向放射治疗计划的设计。方法采用γ射线立体定向放射治疗37例巨大原发性肝癌患者，计划靶区体积（vptv）≥300cm3，PTV周边照射总剂量为3200～3900cGy，分割处方剂量为300～350cGy，每日治疗，6次/周。PTV均由50％～55％等剂量线包绕，每一计划需14～22个等中心。靶区剂量均匀指数为1.60～1.72，无正常组织受照剂量超过相应的耐受剂量。结果本组总有效率（CR＋PR）为78.4％（29/37），无变化（SD）8.1％，进展（PD）13.5％。主要反应为消化道反应，表现为上腹部不适，食欲下降。结论能设计出合格的巨大原发性肝癌的立体定向放射治疗计划，治疗计划所需等中心数多，靶区剂量不均匀。

关键词: 肝癌, 立体定向放射治疗, 治疗计划

Abstract: Objective To study the designing of treatment plan for huge primary liver cancer treated by γ-ray stereotactic radiotherapy. Methods 37 patients with huge primary liver cancer were treated with γ-ray stereotatic radiotherapy（SRT）. Each planning target volume was more than 300 cm3（vptv≥300cm3）. The dose of 3200～3900cGy were delivered to PTVs with the fraction dose of 300～350cGy and 6 consecutive fractions per week. The planning targets were all surrounded by 50％～55％ isodose curve. 14～22 isocenters were needed in each treatment plan in order to cover the PTV by 50％～55％ isodose curve. The index of dose homogeneity of target was 1.60～1.72. There was no normal tissue that couldn’t tolerate the irradiation involved. Results All patients were examined with image of CT or MRI. The total effective rate（CR＋PR），steady disease（SD），progressive disease（PD）was 78.4％，8.1％ and 13.5％，respectively. The main gastrointestinal complications were uncomfortable upper abdomen and poor appetite. Conclusions Qualified treatment plan for huge primary liver cancer treated by γ-ray stereotactic radiotherapy could be designed，but lots of isocenters were needed in the treatment plan and the dose in the target was not homogeneous.

Key words: Hepatoma, Treatment plan, Stereotactic radiotherapy

钟南保,吕光明,陈忠华,季洪兵. 巨大原发性肝癌立体定向放射治疗计划设计[J]. 实用肝脏病杂志, 2011, 14(1): 40-41.

ZHONG Nanbao，LV Guangming，CHEN Zhonghua，et al.. The designing of treatment plan for huge primary liver cancer treated by stereotactic radiotherapy[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2011, 14(1): 40-41.

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巨大原发性肝癌立体定向放射治疗计划设计

The designing of treatment plan for huge primary liver cancer treated by stereotactic radiotherapy

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