Abstract: Objective To study effects of glycine on reducing blood lipids and protecting liver in mice with hyperlipidemia. Methods 40 mice were randomly divided into control，high and low fat diet and glycine-treated groups. Total cholesterol（TC），triglyceride（TG），high density lipoprotein cholesterol（HDL-C），low density lipoprotein（LDL）levels and arteriosclerosis index（AI）were measured after 2 weeks. The activity of superoxide dismutase（SOD）and liver malondialdehyde（MDA）content in livers were also measured. Results TC，LDL，HDL-C，AI and MDA content in high fat diet group increased significantly as compared with in control（P＜0.01）；as compared with high fat diet group，the activity of SOD in liver increased（P＜0.05），MDA in liver decreased（P<0.05）and plasma TC and LDL decreased（P＜0.01） in glycine-treated groups；the hepatic steatosis improved obviously also in livers of glycine-treated mice. Conclusion Glycine can regulate lipid metabolism and enhance the antioxidation to prevent hyperlipidemia and hepatic steatosis.

Key words: Hepatic steatosis, Glycine, Hyperlipidemia, Rats