Abstract: Objective To analyze the relationship between the concentration of serum sodium and prognosis of patients with chronic severe hepatitis B,to compare the difference of predictive value between serum sodium,MELD-Na score and prothrombin time（PT）. Methods 85 patients with chronic severe hepatitis B were divided into the survival group and death group. The level of serum sodium,PT,MELD-Na score were respectively recorded after admission,and analyze the correlation between them. Receiver operating characteristic curve（ROC） and area under the curve （AUC） were used to evaluate the predictive power of serum sodium,MELD-Na score and PT. Results The level of serum sodium,MELD-Na score and PT value in survival group were 136.08± 5.66mmol/L,20.42± 7.78 and 22.28± 6.37 seconds respectively,the level of serum sodium,MELD-Na score and PT value in death group were 131.15± 6.97mmol/L,34.40± 10.72 and 34.48± 10.09s respectively. The level of serum sodium of survival patients were significantly higher than the level of death patients,P< 0.001. The level of serum sodium was negatively correlated with MELD-Na scores（r=-0.673,P< 0.001） and PT （r=-0.238,P< 0.05）. The AUC for serum sodium level,MELD-Na score and the PT value are respectively 0.261,0.878 and 0.870. Conclusion Hyponatremia is an important predict factor for the prognosis of patients with chronic severe hepatitis B. Both MELD-Na scores and PT value can predict short-term prognosis of patients with chronic severe hepatitis B,and the difference between them was not significant.

Key words: [Key words] Chronic severe hepatitis B, serum sodium, MELD-Na score, Prothrombin time, Prognosis