聚桂醇硬化注射术联合生长抑素治疗乙型肝炎肝硬化并发食管胃底静脉曲张破裂出血患者疗效研究*

doi:10.3969/j.issn.1672-5069.2026.03.016

Abstract

Abstract: Objective The aim of this study was to investigate endoscopic lauromacrogol sclerosis injection with combination of intravenous pumping of somatostatin in treatment of patient with hepatitis B-induced liver cirrhosis (LC) and esophageal and gastric variceal bleeding (EGVB). Methods A total of 94 patients with hepatitis B-induced LC and EGVB were encountered in our hospital between May 2023 and May 2025, and were randomly assigned to receive internal comprehensive supporting treatment, including intravenous pumping of somatostatin for 3 to 5 days in 47 cases for control, or underwent endoscopic lauromacrogol sclerosis injection at basis of supporting therapy in the control in another 47 cases. Serum motilin (MTL), somatostatin (SS) and fibrinogen (FIB) levels were detected by radioimmunoassay, and prothrombin time (PT) was detected by blood analyzer. Results Two patients in the control and one in the combination group died of emergent bleeding in our series; total blood transfusion volume in the combination group was (1.9±0.3)U, much less than [(4.1±0.7)U, P＜0.05], and hemostasis time and hospital stay were (15.3±4.5) h and (12.4±2.9)d, both much shorter than [(22.6±5.8)h and (16.8±3.5)d, respectively, P＜0.05] in the control; after hemostasis, serum MLT and SS levels were (210.3±16.2)ng/L and (69.4±11.0)ng/L, both significantly lower than [(285.2±19.3)ng/L and (93.5±14.2)ng/L, respectively, P＜0.05], while serum FIB level was (2.7±0.9)g/L, significantly higher than [(2.0±0.5)g/L, P＜0.05] in the control; re-bleeding rates at 2 week, 1 month and 3 month were 0.0%, 0.0% and 2.2%, all much lower than 11.1%, 17.8% and 31.1%(P＜0.05) in the control group. Conclusion Endoscopic lauromacrogol sclerosis injection in combination with somatostatin in dealing with LC patients with EGVB could obtain rapid hemostasis, and maybe regulate gastrointestinal hormones balance, which warrants further clinical investigation.

Key words: Liver cirrhosis, Esophageal and gastric variceal bleeding, Endoscopic lauromacrogol sclerosis, Somatostatin, Therapy

Zhou Juan, Zhang Ting, Yang Lingjian, et al. Endoscopic lauromacrogol sclerosis injection with combination of intravenous pumping of somatostatin in treatment of patient with hepatitis B-induced liver cirrhosis and esophageal and gastric variceal bleeding[J]. Journal of Practical Hepatology, 2026, 29(3): 381-384.

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Endoscopic lauromacrogol sclerosis injection with combination of intravenous pumping of somatostatin in treatment of patient with hepatitis B-induced liver cirrhosis and esophageal and gastric variceal bleeding

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