第一阶段射血分数联合LVEF和GLS诊断肝硬化心肌病价值研究

doi:10.3969/j.issn.1672-5069.2026.03.014

Abstract

Abstract: Objective The purpose of this study was to investigate diagnostic performance of first-phase ejection fraction (EF1) in combination with left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) in predicting cirrhotic cardiomyopathy (CCM). Methods 127 patients with liver cirrhosis (LC) and 40 healthy individuals for physical examination were encountered in our hospital between July 2024 and June 2025, and all underwent conventional echocardiography for EF1, LVEF and GLS. Receiver operating characteristic (ROC) curve was applied to evaluate diagnostic efficacy. Results CCM was found in 44 cases (34.6%) in our series; LVEF, GLS and EF1 in CCM group were (55.3±4.6)%, (17.4±2.0)% and (24.2±3.4)%, all significantly lower than [(62.1±4.1)%, (21.7±2.2)% and (32.1±3.4)%, respectively, P<0.05] in patients with LC or [(60.9±3.5)%, (20.7±1.9)% and (30.5±2.5)%, respectively, P<0.05] in healthy control; AUC was 0.969, when EF1 in combination with LVEF and GLS was applied to predict CCM in patients with LC, much superior to any parameter did alone. Conclusion EF1 sensitively reflects alterations of left ventricular systolic functions in patients with CCM, and the combination of EF1, LVEF and GLS could help clinicians early screen CCM.

Key words: Liver cirrhosis, Cirrhotic cardiomyopathy, First-phase ejection fraction, Left ventricular ejection fraction, Global longitudinal strain, Left ventricular systolic function, Diagnosis

Yang Xi, Yang Bingbing, Wang Xu, et al. Diagnostic performance of first-phase ejection fraction in combination with LVEF and GLS in predicting cirrhotic cardiomyopathy[J]. Journal of Practical Hepatology, 2026, 29(3): 373-376.

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Diagnostic performance of first-phase ejection fraction in combination with LVEF and GLS in predicting cirrhotic cardiomyopathy

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