Abstract: Objective This study aimed to investigate regional hepatic inflow occlusion (RHIO) for laparoscopic precision liver resection (LPLR) in treatment of patients with primary liver cancer (PLC). Methods 83 patients with PLC were encountered in our hospital between October 2022 and October 2024, all underwent LPLR and for RHIO, they were randomly assigned to either the observation group (n=42) for RHIO, or the control group (n=41) with conventional Pringle maneuver, e.g., intermittent total hepatic inflow occlusion (ITHIO). Serum malondialdehyde (MDA) level was detected by thiobarbituric acid method, and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity were measured by xanthine oxidase method. Peripheral blood lymphocyte subsets was determined by FCM. Results Intraoperative blood loss and operation time in the observation group were much greater or longer than in the control group(P＜0.05); by 3 days after operation, serum bilirubin, AST and INR in the observation group were (20.7±3.2)μmol/L, (38.6±5.1)U/L and (1.1±0.1), all much lower than [(25.7±4.9)μmol/L, (49.8±5.2)U/L and (1.2±0.2), respectively, P＜0.05] in the control; percentage of peripheral blood CD4⁺ cells and CD4⁺／CD8⁺ cell ratio were (62.2±4.9)% and (2.2±1.2), both significantly greater than [(55.3±4.5)% and (1.6±0.2), respectively, P＜0.05] in the control; serum MDA level was (3.4±0.9)mmol/mL, much lower than [(4.2±1.1)mmol/mL, P＜0.05], while serum SOD and GSH-Px levels were(108.5±18.7)U/mL and(69.0±7.8)U/L,both much higher than [(92.2±18.0)U/mL and (61.2±7.2)U/L, respectively, P＜0.05] in the control; post-operationally, incidence of complications in the observation was 28.6%, much lower than 65.9%(P＜0.05) in the control group. Conclusion LPLR under support of RHIO for patients with PLC is superior to under ITHIO, which might lead to mild liver injury and accelerate postoperative recovery.

Key words: Hepatoma, Laparoscopic precision liver resection, Regional hepatic inflow occlusion, Liver injury, Therapy