Abstract: Nucleos（t）ide analogs（NAs） have been successfully used for treatment of chronic hepatitis B. Hepatitis B virus（HBV） replication is now recognized as the key driverof liver injury and disease progression, so the primaryaim of treatment forchronic HBV infection is to maximize sustained suppression of HBV replication to undetectablelevels. The long-term treatment has also beenshown to achieve substantial histological improvement and regression of liver fibrosis orcirrhosis,and reduction of hepatocellular carcinoma. This paper has reviewed the necessity, clinical benefits, and the management of long-term treatment for chronic hepatitis B.

Key words: Hepatitis B, chronic, Nucleoside and nucleotide analogs, Long-term treatment, Management