Abstract: Objective The aim of this study was to summarize clinical feature and prognosis of patients with acute hepatitis E(AHE). Methods Fifty-two patients with AHE were encountered in our hospital between January 2022 and December 2023, and were dealt with conventional liver-protecting measures. Patients with liver failure(LF) were carefully treated by artificial liver supporting system (ALSS) and human blood products. Results Of the 52 patients with AHE, typical AHE was found in 30 cases, and those with hyperbilirubinemia in 17 cases and LF in 5 cases; male percentage, concomitant fatty liver, alcoholic liver disease (ALD) and hospital stay in patients with hyperbilirubinemia were 82.3%, 47.1%, 58.8% and (27.0±6.5)d, all much higher or longer than [63.3%, 10.0%, 13.3% and (15.4±3.0)d, respectively, P<0.05] in those withs AHE; peak total serum bilirubin level (TSB) in patients with hyperbilirubinemia was (195.8±45.6)μmol/L, much higher than [(84.7±23.8)μmol/L, P<0.05] in those with AHE; TSB, albumin and prothrombin time international ratio in patients with LF were(345.2±66.8)μmol/L, (28.9±8.6)g/L and (2.6±0.9); all patients, but two (60.0%)with LF died, got a good prognosis in our series. Conclusion Patients with AHE tends to have hyperbilirubinemia, especially in those with fatty liver or ALD, which might lead to death and needs carefully managed clinically.

Key words: Acute hepatitis E, Hyperbilirubinemia, Liver failure, Prognosis