Abstract: Objective The aim of this study was to compare discrepancy of platelet and coagulation functions between patients with liver cirrhosis (LC) and patients with primary liver cancer (PLC) and underlying LC. Methods A total of 80 patients with LC and another 80 patients with PLC and underlying LC were encountered in Department of Infectious Diseases, Second Affiliated Hospital, Xi 'an Jiaotong University between October 2022 and December 2023, and thromboelastography (TEG) was conducted to record maximum amplitude (MA), react time (R),kinetic time (K),alpha angle (Angle) and clot index (CI). Results There were no significant differences as respect to platelet counts and MA between patients with PLC and LC, although the parameters decreased greatly in both patients of PLC and LC(P>0.05); serum fibrinogen degradation products (FDP) and d-dimer (D-D) levels in patients with PLC were significantly higher than in those with LC (P<0.05); in patients with liver function Child class B/C, MA and CI in 64 patients with PLC were 49.0(40.8, 54.2) and -1.5(-3.7, 0.2), both much greater than [42.5(31.0, 50.2) and -3.2(-7.3,-0.2), respectively, P<0.05], and serum FDP and D-D levels were 5.3(2.9,12.0) μg/mLand 1750.0(870.0, 5285.0)ng/mL, both much higher than [2.1(1.5, 4.0) μg/mLand 740.0(527.5, 1522.5) ng/mL, respectively, P<0.05], while serum fibrinogen level was 1.5(1.1, 2.4) g/L, much lower than [2.1(1.7, 2.7) g/L,P<0.05] in 33 patients with LC. Conclusions Patients with PLC and underlying LC could have even more sophisticated coagulation function disorders, which might involve platelet functionchanges and warrants further investigation.

Key words: Hepatoma, Thromboelastography, Platelet functions