Abstract: Objective The aim of this study was to assess diagnostic performance of ultrasound fine vascular imaging technology (UFVIT) and contrast-enhanced ultrasound (CEUS) in patients with focal liver lesions (FLL). Method This study was conducted on clinical data of 95 patients with FLL who admitted to our hospital between May 2021 and April 2024, and all patients underwent UFVIT and intravenous CEUS examinations. Pathological diagnosis was made on tissues from fine needle aspiration biopsy or from post-operational specimens. Area under receiver operating characteristic curve was applied to evaluate diagnostic efficacy. Result Of 95 patients with FLL, postoperative pathological examination found benign lesions in 51 cases, including focal nodular hyperplasia in 20 cases, hepatic hemangiomas in 31 cases, and malignant lesions in 44 cases, including Cholangiocarcinoma in5 cases and hepatocellular carcinoma in 39 cases; the sensitivity, specificity and accuracy by UFVIT were 81.8%, 78.4% and 80.0%, by CEUS were 68.2%, 76.5% and 72.6%, while by combination of the two methods were 97.7%, 96.1% and 和96.8%, much superior to any one method alone (P<0.05). Conclusion Microvascular imaging technology and intravenous contrast-enhanced ultrasonography has a high accuracy and reliability in distinguishing intrahepatic benign and malignant lesions in patients with FLL, which might help clinicians make a correct interventional measurement.

Key words: Hepatoma, Focal liver lesions, Ultrasound fine vascular imaging technology, Contrast-enhanced ultrasonography, Diagnosis