Abstract: Objective To evaluate serum levels and clinical significance of secreted frizzled-related proteins （sFRP）-1 and β-catenin in patients with hepatocellular carcinoma（HCC）and chronic hepatitis B （CHB）. MethodsSerum levels of sFRP-1 and β-catenin in 36 patients with HCC,36 patients with CHB and 36 healthy persons were detected by ELISA;Spearman correlation analysis was used to estimate the relevance between sFRP-1, β-catenin and age,ALT,albumin,total bilirubin. Results The serum levels of sFRP-1 in patients with HCC and CHB were（1136.28±332.43） pg/ml and（1194.53±156.84） pg/ml,respectively,both significantly higher than that in healthy persons[（1477.26±563.12） pg/ml,P<0.05];The serum level of β-catenin in patients with HCC was （527.2±20.9） pg/ml,significantly higher than those in patients with CHB（374.0±8.3） pg/ml and normal persons （369.8±21.5） pg/ml,P<0.05）;No correlation was found between serum sFRP-1 or β-catenin levels with age,ALT,albumin,total bilirubin either in CHB or in HCC group. Conclusion The serum sFRP-1 levels in patients with HCC and CHB decrease,while the serum β-catenin levels in patients with HCC increase.

Key words: Hepatocellular carcinoma, Hepatitis B, Secreted frizzled-related proteins -1, β, -catenin