七氟醚联合丙泊酚静-吸复合麻醉用于原发性肝癌根治术治疗经验介绍*

doi:10.3969/j.issn.1672-5069.2022.05.024

Abstract

Abstract: Objective The aim of this study was to investigate different dosage of sevoflurane and propofol combination venous-inhalation anesthesia in patients with primary liver cancer (PLC) undergoing radical hepatectomy. Methods A total of 110 patients with PLC were recruited in our hospital between November 2019 and November 2021, and all underwent radical hepatectomy. During anesthesia, the patients were divided into group A (n=54) and group B (n=56), receiving 0.5 minimum alveolar concentration (MAC) or 1.0 MAC sevoflurane and propofol combination intravenous- inhalation anesthesia. The Ramsay sedation, Aldrete scores and mini-mental state examination (MMSE) scores were evaluated. The heart rhythm (HR), mean arterial pressure (MAP) and peripheral oxygen saturation (SpO₂) were recorded. Results The Ramsay sedation scores in group B immediately after extubation was (4.2±0.5), significantly higher than[(3.7±0.4), P＜0.05] in group A, while 5 minutes and 30 minutes after extubation, there were no significant differences respect to Ramsay and Aldrete scores between the two groups (P>0.05); at 6 h, 24 h and 72 h after operation, the MMSE scores in group B were (25.7±2.8), (27.6±1.4) and (28.4±1.1), all significantly higher than[(22.2±3.6), (25.4±2.2) and (27.8±1.2), respectively, P＜0.05] in group A; during operation, the HR in group B was (79.5±11.6)beats/min, faster than[(74.1±12.4)beats/min, P＜0.05] in group A, while before induction of and 6 hr after anesthesia, there were no significant differences respect to the HR, MAP and SpO₂ between the two groups (P＞0.05); the total incidence of adverse reactions in group B was (23.2%, much higher than 7.4%(P＜0.05) in group A. Conclusion The sevoflurane and propofol combination venous-inhalation anesthesia has a good anesthetic effect in the radical surgery of patients with PLC, and as compared with small dose, the administration of large dose of sevoflurane could obtain a better postoperative consciousness recovery, with a little more untoward reactions, which should be carefully evaluated before the operation.

Key words: Hepatoma, Hepatectomy, Sevoflurane, Propofol, Venous-inhalation anesthesia

Fan Shunke, Wang Guiluo,Yi Xiaoyan. Different dosage of sevoflurane and propofol combination venous-inhalation anesthesia in patients with primary liver cancer undergoing radical hepatectomy[J]. Journal of Practical Hepatology, 2022, 25(5): 702-705.

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Different dosage of sevoflurane and propofol combination venous-inhalation anesthesia in patients with primary liver cancer undergoing radical hepatectomy

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