Abstract: Objective The aim of this study was to compare the strategy of intermittent total hepatic inflow occlusion (ITHIO) and regional hepatic inflow occlusion (RHIO) during laparoscopic hepatectomy (LH) in patients with primary liver cancer (PLC). Methods 128 patients with PLC were recruited in our hospital between March 2016 and March 2021, and all patients underwent LH. During the operation, the ITHIO was applied in 57 cases and RHIO was carried out in 71 cases. The mean arterial pressure (MAP), heart rate (HR), and portal vein velocity (PVV) were obtained. Results The intraoperative blood loss and hepatic blood occlusion time in patients with RHIO were (305.4±58.6)mL and (0.0±0.0)min, significantly less or shorter than [(382.5±60.3)mL and (24.2±7.5)min, respectively, P＜0.05] in patients with ITHIO; seven days after operation, serum bilirubin level was (16.4±8.5)μmol/L and serum albumin level was (35.6±5.3)g/L in patients with RHIO, significantly different compared to [(25.7±7.2)μmol/L and (32.4±4.9)g/L, respectively, P＜0.05] in patients with ITHIO; the MAP, HR and PVV in patients with RHIO were (85.6±2.3)mmHg, (78.7±8.3)beats/min and (20.3±0.2)cm/s, not significantly different compared to [(86.8±2.5)mmHg,(79.6±8.1)beats/min and (20.1±0.3)cm/s, P＞0.05] in patients with ITHIO; after operation, the incidences of intraabdominal bleeding, bile leakage, pleural effusion and pulmonary infections in patients with RHIO were 1.4%, 8.5%, 14.1% and 5.6%, not significantly different compared to 3.5%, 10.5%, 22.8% and 10.5% in patients with ITHIO (P＞0.05). Conclusion The strategy of RHIO during LH in dealing with patients with PLC is good with less intraoperative blood loss, shortened hepatic blood occlusion time and alleviation of postoperative liver function recovery.

Key words: Hepatoma, Laparoscopic hepatectomy, Regional hepatic inflow occlusion, Intermittent total hepatic inflow occlusion, Surgery