Abstract: Objective The aim of this study was to investigate the clinical efficacy of partial hepatectomy and choledochojejunostomy combination in the treatment of patients with hepatolithiasis, and to analyze the risk factors for postoperative stone recurrence. Methods 62 patients with hepatolithiasis were enrolled in our hospital between January 2018 and January 2021, and among them, 29 patients in the control were treated with partial hepatectomy and 33 patients in the observation were treated with partial hepatectomy and choledochojejunostomy combination. All patients were followed-up for 1 year after operation. The risk factors for postoperative recurrence was analyzed by multivariate Logistic regression. Results After the operation in both group, serum ALT and AST levels decreased greatly, and total serum bilirubin levels turned back to normal; there was no significant differences as respect to the post-operational complications(9.1% vs. 13.8%, P＞0.05); at the end of one-year follow-up, the ultrasonography showed the stone recurrence rate in the observation was 15.2%, significantly lower than 41.4%(P＜0.05) in the control; out of the 62 patients with hepatolithiasis, 17 cases (27.4%)had intrahepatic stone recurrence after operation; the univariate Logistic regression analysis showed that the residual stone, biliary stricture and the operation itself were different between patients with and without stone recurrence, and the multivariate Logistic regression analysis demonstrated that residual stone [OR(95%CI):3.5(1.3-9.6)] and biliary stricture [OR(95%CI):2.7(1.1-6.6)] were the risk factors for post-operational stone recurrence, while the partial hepatectomy and choledochojejunostomy [OR (95%CI) :0.3 (0.1-0.9)] was the good choice for patients with hepatolithiasis. Conclusion The partial hepatectomy and choledochojejunostomy combination in the treatment of patients with hepatolithiasis could reduce the risk of postoperative stone recurrence, which warrants further clinical investigation.

Key words: Hepatolithiasis, Partial hepatectomy, Choledochojejunostomy, Therapy, Stone recurrence