Abstract: Objective The aim of this study was to analyze the clinical application of ultrasound-guided percutaneous aspiration (PA) and percutaneous catheter drainage (PCD) for treatment of liver abscess patients with or without acquired immune deficiency syndrome (AIDS). Methods The clinical data of 74 patients (with underlying AIDS in 39) with liver abscess were admitted to our hospital between June 2013 and December 2019, and all patients underwent PA or/ and PCD for treatment at base of supporting management. Results The main clinical manifestations in the two groups were fever, and the incidence of abdominal pain or abdominal discomfort in AIDS group was 56.4%, significantly higher than that in non-AIDS group (31.4%, P< 0.05); in AIDS group and non-AIDS group, the white blood cell count was 7.2×10⁹/L and 10.6×10⁹/L, and the percentage of neutrophil was 73.7% to 78.8% (P< 0.05); serum C-reactive protein (CRP) levels were 62.8 mg /L and 120.9 mg/L (P< 0.05), while serum procalcitonin levels were 0.3 g/L and 0.4 g/L (P﹥0.05) ; the incidence of extrahepatic infection in AIDS group was 71.8%, significantly higher than 48.6% in non-AIDS group (P< 0.05) ; it was difficult to culture out pathogens from pus from AIDS patients, and the pathogens varied, while the lebsiella pneumoniae was the main pathogen in patients without AIDS; in AIDS group and non- AIDS groups, the size of abscess were 9.4 ± 3.6 cm and 9.0 ± 3.1 cm (P>0.05), the postoperative complications were 17.9% and 8.6%, and the cure rate was 87.2% and 94.3% (P>0.05). Conclusion The patients with AIDS and liver abscess have their unique clinical features, and the interventional therapy under ultrasound guidance is safe, reliable and efficacy.

Key words: Liver abscess, Acquired immune deficiency syndrome, Ultrasound guidance, Percutaneous aspiration, Percutaneous catheter drainage, Therapy