Abstract: Objective The aim of this study was to investigate serum cytokine changes in patients with nonalcoholic fatty liver diseases (NAFLD) and helicobacter pylori (HP)infection after clearance therapy. Methods 84 patients with NAFLD and HP infection were enrolled in our hospital between October 2018 and October 2020, and were randomly divided into observation and control group with 42 cases in each group. All patients received diet-control and exercise guidance, and those in the observationgroup received conventional four medicine combination for Hp eradication. Serum IL-6, IL-18 and TNF-α levels were detected by ELISA, and the homeostasis model assessment of insulin resistance index (HOMA-IR) was calculated. Results The Hp infection was eradicated in all patients in the observation group; after treatment, serum IL-6,IL-18 and TNF-α levels in the observation group were (23.4±8.0)pg/ml, (43.7±8.2)pg/ml and (1.5±0.4)ng/L, all significantly lower than [(30.6±6.8)pg/ml, (49.5±10.1)pg/ml and (1.7±0.5)ng/L, respectively, P<0.05] in the control; there were no significantly differences as respect to serum AST levels [(50.8±10.9)U/L vs. (48.1±9.9)U/L], serum ALT levels [(69.3±13.5)U/L vs. (71.8±8.7)U/L] and serum GGT levels [(84.8±16.7)U/L vs. (86.2±20.3)U/L] between the two groups (P>0.05); the HOMA-IR in the observation group was (2.3±1.1), significantly lower than [(3.3±1.2), P <0.05] in the control, while there were no significant differences respect to fasting blood glucose levels [(6.3±1.0)mmol/L vs. (6.5±0.8)mmol/L] and blood glucose level at two hour after meal [7.3±0.9)mmol/L vs. (7.9±1.1)mmol/L] between the two groups(P >0.05); there was no significant difference in blood ester between the two groups(P >0.05). Conclusion The eradication of HP infection could inhibit inflammatory reaction in patients with NAFLD and HPinfection, which warrants further investigation for its impact on hepatic steatosis.

Key words: Nonalcoholic fatty liver diseases, Helicobacter pylori infection, Cytokines, Eradication therapy