Abstract: Objective The aim of this study was to investigate the application of Viatorr coated stent during the transjugular intrahepatic portosystemic shunt (TIPS) in the treatment of patients with liver cirrhosis and portal hypertension.Methods 146 patients with liver cirrhosis and portal hypertension were recruited in our hospital between January 2018 and January 2020, and were randomly divided into control (n=73) and observation (n=73) groups.All patients underwent TIPS, while the bare and the Fluency stent were used in patients in the control and the Viatorr stent was used in the observation. All patients were followed-up for 12 months.Results The operation time in the observation group was (99.5±9.8) min, significantly shorter than [(110.0±8.5) min, P<0.05] in the control, and there was no significant difference in portal vein pressure after operation between the two groups (P>0.05); at the end of 3 months after operation, there were no significant differences as respect to serum hepatic function tests between the two groups (P>0.05); at the end of 12 months, the shunt insufficiency rate in the observation group was 1.4%, significantly lower than 23.3% in the control group (P<0.05); five patients (6.8%)in the observation, and six(8.2%, Log-rank=0.099, P=0.753)in the control died.Conclusion The application of Viatorr covered stent during TIPS for treatment of cirrhotic patients with portal hypertension could effectively shorten the operation time and keep the shunt patency, which warrants further investigation.

Key words: Liver cirrhosis, Portal hypertension, Transjugular intrahepatic portosystemic shunt, Viatorr covered stent, Therapy