Abstract: Objective The aim of this study was to summarize the clinical features of patients with malignant lymphoma (ML) and liver dysfunction. Methods The clinical manifestations, imaging features, pathological findings and clinical outcomes were summarized by retrospective analysis. Results The age of 9 patients was 48.47±16.02 (16～78) years; 8 complained of asthenia, 3 had fever, 5 had yellow skin and eye; serum ALT level was 192.3±292.8 u/l, AST was 192.6±222.9 U/L, serum bilirubin level was 120.4±89.5μmol/L; 7 had liver and spleen enlargement; bone marrow biopsies were performed in 5 cases, liver biopsies were in 2 cases, lymph node examination in 2 cases and gastric mucosa pathology in 1 case, all of which indicated B-cell-arose lymphoma; chemotherapy were given in 6 cases and 3 cases died, and 3 cases received regular chemotherapy and followed-up. Conclusions It is necessary to consider the possibility of ML in patients with abnormal liver function and unexplained hepatosplenomegaly. The pathological examination of liver and/or bone marrow could help the confirmation of the diagnosis.

Key words: Liver dysfunction, Lymphoma, Clinical features, Literature review