Abstract: Objective To investigate the changes of serum IL-10 and soluble intercellular adhesion molecule-1 （sICAM 1） levels in patients with hepatitis B-induced liver cirrhosis （LC）.Methods A total of 79 patients with hepatitis B-induced LC, including 31 with Child-Pugh class A, 25 with Child-Pugh class B and 23 with Child-Pugh class C,were enrolled in our hospital between September 2014 and August 2016, and 23 healthy persons were selected as control. Serum interleukin（IL）-2,IL-6,IL-10 and sICAM 1 levels were detected by enzyme-linked immunosorbent assay.Results Serum IL-10 levels in patients with compensated and decompensated LC were （43.5±8.4） g/L and （55.8±6.1） g/L,respectively,much lower than （247.1±43.4） g/L （P<0.01） in healthy persons,while serum IL-2,IL-6 and sICAM-1 levels were （148.1±21.3） g/L,（43.5±8.4） g/L and （298.5±85.7）ng/mL,and （180.6±17.1） g/L,（55.8±6.1） g/L and （685.4±164.8） ng/mL, respectively,significantly higher than （22.6±6.0）g/L,（6.6±1.5） g/L and （158.7±21.5） ng/mL in healthy control （P<0.05）;serum IL-10 level in 23 patients with Child-Pugh class C was（84.3±11.4） g/L,much lower than（121.3±14.6） g/L in 31 patients with Child-Pugh class A or（101.4±12.6） g/L in 25 with Child-Pugh class B （P<0.05）,while serum IL-2,IL-6 and sICAM-1 levels were （182.7±31.4） g/L,（57.3±7.3） g/L and（665.0±135.5） ng/mL,much higher than （138.4±19.6） g/L,（42.4±6.6） g/L and （398.7±103.3） ng/mL,in patients with Child-Pugh class A or （157.7±22.3） g/L,（49.9±6.2） g/L and （509.6±122.9） ng/mL in patients with Child-Pugh class B（all P<0.05）;serum IL-10 levels decreased,while serum IL-2,IL-6 and sICAM-1 levels increased in patients with complications such as spontaneous bacterial peritonitis,hepatic encephalopathy or gastrointestinal bleeding. Conclusion Serum cytokine levels change as liver functions deteriorate, which might be helpful for clinicians to make managements in time in clinical practice.

Key words: Liver cirrhosis, Hepatitis B, Soluble intercellular adhesion molecule-1, Interleukin-10