Abstract: Objective To investigate the prognosis of patients with hepatocellular carcinoma（HCC） and underlying chronic hepatitis B（CHB）. Methods 469 patients with CHB-related HCC were recruited in our hospital between January 2008 and November 2015,and 243（51.8 %） of them had low serum HBV loads （HBV DNA<1×10⁴ copies/ml） and 226 （48.2%） had high （HBV DNA≥1×10⁴ copies/ml）. The baseline characteristics,nucleoside analogues（NAs） treatment,serum HBV DNA loads and liver function index was recorded. The prognosis of patients in the two groups was analyzed by Logistic analysis. Result The average age in patients with low and in with high serum HBV load were （54±10） yr and （52±10） yr,no significant difference （P>0.05）;the men in patients with low serum HBV DNA were 213 （87.7%）,while the percentage of men was 90.7 %,no significant difference between them （P>0.05）;serum ALT and AST levels in patients with low serum HBV DNA were （80±105） u/L and （55±72） u/L,respectively,much lower than （114±130） u/L and （80±107） u/L in patients with high serum HBV load （P<0.05）;the survival time in patients with low serum HBV load was（1144±732） d,much longer than [（496±278） d,P<0.05] in patients with high serum HBV load;univariate analysis showed that anti-rival therapy,serum AFP level≥40 μg/L,serum ALT level ≥64 IU/L,serum AST level≥40 IU/L,serum bilirubin level≥24 μmol/L and serum HBV DNA load≥1×10⁴ copies/ml were the factors affecting the survival of patients with HCC（P<0.001）;multivariate analysis showed than the BCLC stage（HR=1.84,CI 为1.57-2.15,P<0.001）,without anti-viral therapy （P<0.01）, serum AST≥40 IU/L （P<0.05） and serum HBV DNA ≥1×10⁴ copies/ml （P<0.001） were the independent factors for poor prognosis of patients with hepatitis B-related HCC. Conclusions Many factors impact the survival of patients with CHB-related HCC,and serum HBV loads and anti-viral therapy might be taken into consideration in clinical practice.

Key words: Chronic hepatitis B, HCC, HBV DNA, NAs, prognosis