Abstract: Objective To explore the risk factors of portal vein thrombosis（PVT） occurrence in patients with liver cirrhosis. Method The clinical data of 444 patients with liver cirrhosis recruited in our hospital between March and December 2016 were retrospectively analyzed. Out ot them,44 had PVT,and 400 without. The clinical data in the two groups were collected and compared. The t-test or Chi-square test was used to analyze the risk factors for PVT,and univariate and multivariate Logistic regression model were applied to analyze the independent risk factors. Results Univariate analysis showed that there were significant differences as respect to Child-Pugh score,hemoglobin （HB）,platelet（PLT）,D-dimer,fibrinogen degradation product （FDP）,albumin （ALB）,portal vein diameter,spleen length,spleen thickness,portal vein flow rate and the incidence of diabetes between the two groups （P<0.05）;multivariate Logistic regression analysis showed that portal vein diameter （OR=1.258,95%CI 1.035~1.616,P=0.009）,D-dimer（OR=3.915,95%CI 2.243~5.796,P=0.000）,and diabetes （OR=4.189,95%CI 2.067~6.231,P=0.000） were the independent risk factors for the formation of PVT. Conclusion There are many factors influencing the occurrence of PVT,whereas increased blood D-dimer levels,widened portal vein diameter and diabetes are the independent risk factors in patients with liver cirrhosis. which should be taken into consideration in clinical practice.

Key words: Liver cirrhosis, Portal vein thrombosis, Risk factor