Abstract: Objective To investigate the quantitative diagnosis of liver functions in patients with liver cirrhosis by multi-slice spiral CT-calculated liver volume. Methods 70 patients with liver cirrhosis were recruited in this study between April 2015 and April 2017，and all the patients received multi-slice spiral CT examination. The theoretical and practical liver volumes were calculated according to the reported methods. Results The CT-determined practical liver volumes in 28 patients with Child-Pugh class C，25 with class B and 17 with class A were（712.07±65.89） cm3，（832.17±80.46） cm3 and（992.51±299.02） cm3，much lower than the theoretical liver volumes [（1415.74±126.81） cm3，（1458.29±164.17） cm3 and （1498.93±114.39） cm3，respectively，P<0.05]；the CT liver volumes in 22 patients with MELD score≥20，in 30 with 20>MELD score ≥10 and 18 with MELD score<10 were（757.83±39.04） cm3，（813.84±80.97） cm3 and（982.09±281.75） cm3，significantly lower than the theoretical liver volumes[（1461.57±65.23） cm3，（1481.19±155.85） cm3 and（1482.12±87.26） cm3，respectively，P<0.05]. Conclusions Multi-slice spiral CT-calculated liver volume might be used as a quantitative diagnosis of liver functions in patients with hepatitis B cirrhosis.

Key words: Liver cirrhosis, Multi-slice spiral CT, Liver volume, Quantitative diagnosis