Abstract: Objective To investigate the efficacy of ultrasound（US）-guided percutaneous aspiration in treatment of patients with purulent liver abscess（PLA） and its effects on blood cytokine levels. Methods 78 patients with PLA were recruited in our hospital between March 2014 and March 2017,and they were randomly divided into two groups by computer-generated numbers. The patients in observation group were treated by direct aspiration under US guidance,and those in the control were treated by percutaneous transhepatic catheter drainage under US guidance. Serum interleukin（IL）-6）,IL-8 and tumor necrosis factor-α（TNF-α） were detected by ELISA,and blood procalcitonin level was routinely assayed. Results The time of abscess disappearance in the observation was （9.0±0.9） d,much shorter than（13.0±1.3） d in the control （P<0.05）,while there were no significant differences between the two groups as respect to pain disappearance,temperature returned to normal,hospital stay and medical costs [（1.3±0.1） d,（2.2±0.2） d,（12.3±1.3） d and （14000±100） yuan vs. （1.4±0.1） d,（2.3±0.3） d,（12.7±1.4） d and （14000±100） yuan, respectively,P>0.05];there were no significant differences between the two groups as respect to blood biochemical parameters before and after the treatment （P>0.05）;in the observation group at the end of the treatment,peripheral blood white blood cell counts was（7.2±1.3）×10⁹/L,neutrophil ratio was（0.7±0.1） and serum procalcitonin level was（0.3±0.1） ng/ml,without significant difference as compared to （8.7±1.5）×10⁹/L,（0.7±0.1） and （0.4±0.1） ng/ml（P>0.05） in the control;serum IL-6 level was （0.1±0.1） ng/mL,IL-8 level was（0.1±0.0） ng/ml and TNF-α level was （0.2±0.0） μmol/L,without significant difference as compared to （0.1±0.0） ng/ml,（0.1±0.0） ng/ml and （0.2±0.1） μmol/L in the control （P>0.05）;the local infection occurred in one,bleeding in one and the drainage tube fell off in one in the control. Conclusion Ultrasound-guided percutaneous puncture aspiration in the treatment of patients with PLA have good clinical efficacy and safety.

Key words: Purulent liver abscess, Ultrasound-guidance, Percutaneous puncture, Efficacy