Abstract: Objective To investigate the clinical application of serum neutrophil gelatinase associated apolipoproteins（NGAL） and serum creatinine（sCr） in the early diagnosis of hepatorenal syndrome（HRS） in patients with liver cirrhosis. Methods The clinical data of 108 patients with hepatitis B-induced liver cirrhosis in our hospital between March 2014 and March 2017 were retrospectively analyzed. Out of them,45 patients had HRS,and 63 had not. 66 persons for physical examination at the same time in our hospital were selected for the control. Serum NGAL and Cr in three groups were determined routinely. The early diagnostic value of serum NGAL and Cr in patients with hepatitis B cirrhosis complicated by HRS was analyzed by area under ROC. Results Serum NGAL and Cr levels in HRS group were （64.1±18.4） ng/ml and（109.6±24.5） μmol/L,which were significantly higher than [（10.6±3.1） ng/ml and（88.2±15.7） μmol/L,P<0.05] in patients without HRS or [（8.3±2.2） ng/ml and（82.6±14.3） μmol/L,P<0.05] in the control,and serum NGAL and Cr levels were not significant different between the control group and non-HRS group（P>0.05）;The Spearman correlation analysis showed that serum NGAL and Cr were negatively correlated with 24-Ccr（r=-0.768,P<0.01;r=-0.721,P<0.01）;The AUC of combination of NGAL and sCr in the diagnosis of HRS was 0.895（0.860-0.912） with a sensitivity of 82.5%,the specificity of 83.4% and the accuracy of 75.8%,which were significantly higher than those by any of the single parameters[the AUC of ROC_NGAL was 0.751（0.708-0.794） with a sensitivity of 75.3%,specificity of 84.5% and the accuracy of 63.84%; and the AUC of the ROC_sCr was 0.743（0.714-0.772） with a sensitivity of 73.2%,a specificity of 66.8% and the accuracy of 56.38%]. Conclusion The application of serum NGAL in the early diagnosis of hepatorenal syndrome in patients with liver cirrhosis is helpful,and the sensitivity and specificity of combination of serum NGAL and Cr is more practical,which can improve the early diagnosis of hepatorenal syndrome in patients with liver cirrhosis.

Key words: Liver cirrhosis, Hepatorenal syndrome, Neutrophil gelatinase associated apolipoproteins, Clinical diagnosis