Abstract: Objective To investigate the clinical features,pathogenic distribution and drug susceptibility in patients with liver cirrhosis complicated by spontaneous bacterial peritonitis（SBP）. Methods 60 bacteria-culture positive patients with hepatitis B-induced liver cirrhosis complicated by SBP were analyzed in this study,and the bacteria were characterized by KB paper dispersion or MIC. Results Out of the 60 patients with SBP,we obtained Escherichia coli（E. coli） in 8（7.1%）,Klebsiella pneumoniae（KPN） in 7（11.7%）,Baumanii in 10（16.7%）,P. aeruginosa in 6（10.0%）,A. cloacae in 4（6.7%）,E. aerogenes in 3（5.0%）,coagulase-negative Staphylococcus （CNS） in 14（23.3%） and Enterococcus in 8（13.3%）;there were 2 strains of E. coli,2 strains of KPN,1 strain of Baumanii,2 strains of P. aeruginosa,2 strains of A. cloacae,and 1 strain of E. aerogenes resistant to cefoxitin; 1 strain of E. coli,1 strain of KPN,3 strains of Baumanii,1 strain of P. aeruginosa,and 2 strains of E. Aerogenes resistant to ceftriaxone;3 strains of E. coli, 3 strains of KPN,2 strains of Baumanii,1 strain of P. aeruginosa and 3 strains of E. Aerogenes resistant to imipenem;8 strains of CNS and 2 strains of Enterococcus resistant clindamycin,and 1 strain of CNS resistant to vancomycin. Conclusion s It's difficult to separate bacteria in patients with SBP,and the positive bacteria obtained in clinical practice are main Gram negative bacilli, which are susceptible to imipenem,and the Gram positive are sensitive to vancomycin.

Key words: Spontaneous bacterial peritonitis, Liver cirrhosis, Bacteria separation, Drug sensitivity