Abstract: Objective To study the impact of nucleos（t）ide analogues on estimated glomerular filtration rate（eGFR） in patients with chronic hepatitis B. Methods A retrospective study of 40 patients treated with tenofovir （TDF）,56 patients with telbivudine （LDT） and 68 patients with entecavir （ETV） were conducted in this study,and all CHB patients were naive,and the eGFR was evaluated by using the Cooperative Formula for Chronic Kidney Disease Epidemiology（CKD-EPI） equation. Results The eGFR in ETV-treated and TDF-treated group at the end of 24 month treatment were （89.5±13.2） ml·min^-1·1.73 m^-2 and （93.8±13.2） ml·min^-1·1.73 m^-2, both significantly lower than those at baseline【（93.4±9.8） ml·min^-1·1.73 m^-2,P=0.041 and （98.6±11.2） ml·min^-1·1.73 m^-2,respectively,P=0.016】,while the eGFR in LDT-treated group was（108.5±10.9） ml·min^-1·1.73 m^-2, significantly higher than that at baseline 【（96.6±10.3） ml·min^-1·1.73 m^-2,P=0.002】;the eGFR in 3 groups at baseline was not statistically significantly different（P=0.870）,while they were statistically significantly different in the three groups as respect to the proportion of eGFR less than 90 ml·min^-1·1.73 m^-2（P=0.028）;at the end of 24 month treatment,16.7% （3/18） in ETV-treated, and 44.4% （4/9） in TDF-treated groups with normal renal function at baseline progressed to eGFR <90 ml·min^-1·1.73 m^-2,while 69.2% （9/13） of LDT-treated patients with renal impairment at baseline got renal function returned to normal （≥90 ml·min^-1·1.73 m^-2）. Conclusion The long-term application of LDT might have a protective effect on renal function, whereas the administration of TDF and ETV might result in decreased of eGFR.

Key words: Hepatitis B, Nucleos（t）ide analogue, Estimated glomerular filtration rate