Abstract: Objective To evaluate the efficacy of combination of entecavir and Chinese herbal medicine in treatment of patients with hepatitis B. Methods 69 patients with hepatitis B were enrolled between January 2015 and December 2016 in this study. 34 patients with hepatitis B received combination of entecavir and herbal medicine,and 35 patients with hepatitis B received entecavir alone for 24 weeks. The data of liver function index and serum liver fibrosis markers were compared. SPSS 19.0 statistical software was applied to complete the data processing and analysis. Results There was no significant difference in serum albumin level between the two groups before and after the treatment （P>0.05）,while there were significant differences as respect to serum bilirubin, alanine aminotransferase,and aspartate aminotransferase levels between the two groups （P<0.05）,e.g. serum bilirubin level in the combination group at the end of 24 weeks was（20.1±4.7） μmol/L,much lower than（28.7±4.8）μmol/L in the controls （P<0.05）,serum ALT leves was （40.9±6.8） U/L,much lower than （50.2±6.7） U/L in the control （P<0.05）,and serum AST level was （39.6±8.4） U/L,much lower than （52.5±8.1） U/L in the control （P<0.05）;at the end of observation,serum HA,LN,IV-C and PC-Ⅲ levels decreased both in the two groups,e.g. serum HA level in the combination group decreased from [（256.3±9.3） μg/L to（98.3±9.1）μg/L,while serum HA levels in the control decreased from （255.3±9.8） μg/L to（140.3±9.6） μg/L,serum LN level in the combination decreased from[（241.3±7.8） μg/L to （110.3±7.7） μg/L,seerum LN level in the control decreased from [（240.4±7.8） μg/L to （170.5±7.9） μg/L,serum IV-C levels in the combination decreased from [（98.4±6.8） μg/L to（53.6±6.7）μg/L,serum IV-C level in the control decreased from [（98.00±6.5） μg/L to （70.9±6.6） μg/L,serum PC-Ⅲ level in the combination decreased from [（193.6±13.2） μg/L to（98.3±9.9） μg/L,while serum PC-Ⅲ levels in the control decreased from [（193.5±13.4） μg/L to（120.3±9.7） μg/L（P<0.05）;there was no significant differences as respect to serum HBeAg and/or HBV DNA negativity in the two groups（P>0.05）. Conclusion Combination of entecavir and Chinese herbal medicine can quickly inhibit HBV replication,and enhance the efficacy of anti-liver fibrosis.

Key words: Hepatitis B, Entecavir, Herbal medicine, Hepatic fibrotic markers