Abstract: Objective To investigate the effect of compound embryonic bovine liver extract and adefovir dipivoxil treatment on patients with chronic hepatitis B. Methods 42 patients with choronic hepatitis B were divided randomly to two groups. Treatment group was treated with compound embryonic bovine liver extract tablets and adefovir dipivoxil tablets,and control group was treated with adefovir dipivoxil tablets. The regimen lasted for 48 weeks in the two groups. The liver inflammation activity grades and fibrosis stages and serum hyaluromic acid（HA） level before and after treatment in two groups were obtained. Results Grades of liver inflammation activity and stages of fibrosis decreased obviously in treatment group than in control group（P<0.05）. At the end of the therapy,serum HA level decreased significantly in treatment group（P<0.001）and there was no decrease in control group（P<0.001）. Conclusion Combined therapy of compound embryonic bovine liver extract tablets and adefovir dipivoxil tablets was better than adefovir dipivoxil tablets alone in patients with chronic hepatitis B.

Key words: Hepatitis B, Compound embryonic bovine liver extract, Liver inflammation activity, Adefovir