Abstract: Objective To investigate the clinical and pathological features of HBeAg negative and positive chronic hepatitis B patients complicated with fatty liver. Methods In 120 patients with chronic hepatitis B（CHB）,the liver biopsy was conducted,and blood biochemical parameters and serum HBV DNA were tested respectively. Results Among 120 patients with CHB,68 were HBeAg positive（56.7%）,and 52 HBeAg negative （43.3%）. In patients with HBeAg positive,we found fatty liver disease in 11（16.2%）,much lower than 18（34.6%,P<0.05）in HBeAg negative patients;Serum triglyceride and γ-glutamyltranspeptidase levels in HBeAg positive patients with fatty liver disease were higher than in HBeAg positive patients without（P<0.05）;In patients with fatty liver disease,the average ages（36.2±14.6y-o）and hepatic fibrosis scores（2.6±0.8）in HBeAg negative were significantly higher than in HBeAg positive group（28.2±11.3y-o and 2.0±0.7,respectively,P<0.05）,while body mass index（20.1±5.1）,triglyceride（1.5±0.4mmol/L）and HBV DNA load（4.4±2.6 lgcopies/mL）were lower than in HBeAg positive（27.3±4.0,3.7±0.4 mmol/L,6.8±1.3 lgcopies/mL,respectively（P<0.05）. Conclusion The prevalence of fatty liver disease in HBeAg negative CHB patients is relatively higher,so they should be checked-up as early as possible.

Key words: Hepatitis B, HBeAg, Fatty liver disease