Abstract: Objective The aim of this study was to evaluate diagnostic performance of six non-invasive evaluation scores for type 2 diabetes mellitus (T2DM) with metabolic associated fatty liver disease (MAFLD). Methods A total of 282 patients T2DM, of them MAFLD was diagnosed in 158 cases, were enrolled in our hospital between January and December 2023, and from conventional clinical materials, metabolic score for insulin resistance (METS-IR), triglyceride-glucose index(TyG), triglyceride glucose-body mass index (TyG-BMI), hepatic steatosis index (HSI), Framingham steatosis index (FSI) and Zhejiang University index (ZJUI) were calculated. The diagnostic efficacy of these scores was assessed by using receiver operating characteristic (ROC) curve analysis. Results All the six non-invasive evaluation scores were significantly greater in patients with T2DM and MAFLD than in those with T2DM (P<0.05); the predicting AUC by TyG-BMI was 0.857(95% CI:0.814-0.900), and the AUC by ZJUI was 0.852(95% CI:0.808-0.896), suggesting both having a satisfactory diagnostic performance. Conclusion Both TyG-BMI and ZJU index have an excellent predictive value for identifying MAFLD from patients with T2DM, offering potential tools for clinical screening and monitoring.

Key words: Metabolic dysfunction-associated fatty liver disease, Type 2 diabetes mellitus, Triglyceride glucose-body mass index, Zhejiang University index, Receiver operating characteristic curve, Diagnosis