Abstract: Objective The aim of this study was to investigate the expression of fibroblast growth factor receptor 2 (FGFR2) in cancerous tissues and its implication in patients with intrahepatic cholangiocarcinoma (ICC) underwent radical hepatectomy. Methods 56 patients with ICC were encountered in our hospital between March 2017 and April 2022, and all underwent radical hepatectomy. All patients were followed-up for one year. The expression of FGFR2 in cancerous tissues was detected by immunochemical staining. The univariate and multivariate Logistic regression analysis were applied to predict the factors impacting the disease-free survival (DFS). Results The expression of FGFR2 in cancerous tissues was positive in 15 cases(26.8%) and negative in 41 cases (73.2%); the incidence of microvascular invasion in FGFR2 positive group was 66.7%, significantly higher than 29.3% in FGFR2 negative group (P<0.05); serum CEA level in FGFR2 positive group was 5.9(1.3, 55.2)ng/mL, much higher than [2.2(0.5, 26.4)ng/mL, P<0.05] in FGFR2 negative group; at the end of one-year follow-up, the DFS in FGFR2 positive group was 33.3%, much lower than 58.5%(P<0.05) in FGFR2 negative group; the multivariate Logistic regression analysis showed that the tumor diameters, the locations of tumor and the FGFR2 positive expression were the independent risk factors impacting the prognosis of patients with ICC after operation (P<0.05). Conclusion The intensified expression of FGFR2 in cancerous tissues is an independent risk factor for postoperative recurrence of tumor and poor prognosis in patients with ICC, which should be taken into consideration for close surveillance.

Key words: Intrahepatic cholangiocarcinoma, Fibroblast growth factor receptor 2, Expression, Prognosis