Abstract: Objective The aim of this study was to investigate the implication of interleukin-6 (IL-6) gene polymorphism in short-term prognosis of patients with hepatitis B-inducedacute-on-chronic liver failure (HBV-ACLF). Methods 134 patients with HBV-ACLF were admitted to our hospital between April 2017 and April 2020. The single nucleotide polymorphisms (SNPs) of rs1524107, rs2069837, rs2069840 and rs2069845 of IL-6 gene were detected by imLDRTM multiple SNP typing kit. Results Out of the 134 patients with HBV-ACLF, the 90 day survivalrate was 73.9% with 35 dead; the peak total serum bilirubin level and prothrombin time international standardized ratio in dead patients were(399.3±168.8)μmol/L and (2.3±0.8), both significantly higher than[(285.9±121.5)μmol/L and (1.7±0.4), respectively, P＜0.05] in survived patients, while there were no significant differences as respect toserum albumin, creatinine, procalcitonin, white blood cell counts and platelet counts (P＞0.05); the distributions of rs1524107, rs2069837, rs2069840 and rs2069845 conform to Hardy-Weinberg genetic equilibrium law (P>0.05), and possess population representative; the genotype frequency distribution of rs1524107, rs2069837, rs2069840 and rs2069845 in the two groups showed no statistically significant difference (P>0.05), and the allele frequency distribution of rs1524107, rs2069837, rs2069840 and rs2069845 in the two groups also showed no statistical significance (P>0.05). Conclusion The SNPs of IL-6 rs1524107, RS2069837, rs2069840 and RS2069845 in survived and dead patients with HBV-ACLF have no significant differences, so the detection could not predict the prognosis of patients in this setting and might deal with them routinely.

Key words: Acute-on-chronic liver failure, Hepatitis B, Interleukin6, Single nucleotide polymorphism, Prognosis